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, start with a research question
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Explore sample research questions
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Clinical Medicine
Are GLP-1 receptor agonists effective and safe for long-term weight loss?
Does metformin reduce progression from prediabetes to type 2 diabetes in real-world studies?
Is early physical therapy effective for reducing pain and disability in low back pain?
Are proton pump inhibitors associated with increased risk of kidney disease?
What is the comparative effectiveness of CBT vs SSRIs for generalized anxiety disorder?
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Healthcare
Does long-term PM2.5 exposure increase risk of dementia?
Do ultra-processed foods increase risk of cardiovascular disease?
What is the association between heat exposure and cardiovascular mortality among outdoor workers?
Does night shift work increase risk of type 2 diabetes and metabolic syndrome?
How strongly is alcohol consumption linked to all-cause mortality across dose ranges?
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Environment
What is the association between long-term PM2.5 exposure and cardiovascular mortality?
How does climate change affect the frequency and intensity of heatwaves globally?
Do microplastics in drinking water pose measurable risks to human health?
How effective is carbon capture and storage at reducing industrial CO2 emissions at scale?
What are the biodiversity impacts of renewable energy expansion (wind/solar) on local ecosystems?
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Technology
How reliable are common LLM evaluation benchmarks at predicting real-world performance?
How accurate are AI models for detecting breast cancer on mammography?
Do wearables reliably detect atrial fibrillation compared to clinical ECG?
What techniques best reduce hallucinations in medical or scientific LLM outputs?
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Fitness & Nutrition
Do ultra-processed foods increase risk of cardiovascular disease and mortality?
Is intermittent fasting more effective than daily calorie restriction for fat loss and metabolic health?
Does resistance training reduce depression and anxiety symptoms compared to no exercise?
How does sleep duration and quality affect body composition and appetite regulation?
Are plant-based diets associated with lower risk of type 2 diabetes and heart disease?
