Alzheimer's Disease
The role of stress as one of the trigger factors in the aging of the hippocampus structures and its damage in Alz-heimer's disease and changes in cerebral microcirculation, the state of the blood-brain barrier and the participation of stress-related mechanisms in them as a single complex are discussed.
Abstract
The aim of the work was the studying of stress changes in the hippocampus microvascular bed in male rats under chronic immobilization and chronic emotionally painful stresses. Lesions were found in the hippocampus CA1 and CA3 fields accom-panied by dystrophic changes in neurons and their death. Simultaneously, the development of microvascular involvement (mainly, capillaries and a postcapillary-venular part) with destruction of the blood-brain barrier structures is revealed. The arti-cle discusses the role of stress as one of the trigger factors in the aging of the hippocampus structures and its damage in Alz-heimer's disease. The data obtained give reason to consider the problems of age-related neurodegenerative lesions, changes in cerebral microcirculation, the state of the blood-brain barrier and the participation of stress-related mechanisms in them as a single complex.