A CRH-HCN Theory of Obsessive-Compulsive Disorder (OCD)

Abstract

I present the first complete theory of OCD. OCD occurs when excessive CRH is released in the prefrontal cortex, activating cAMP. cAMP is a major inducer of HCN channels, which promote repeated neural firing. The combination of CRH, which is strongly associated with stress, and repeated firing that cannot be controlled, explains all of the features of OCD, including obsessions and compulsions of all kinds.