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Clean and safe drinking water is one of the most important and essential components on earth for human survival. However, due to the various anthropogenic activities, the surface and groundwater have been contaminated with heavy metals and radionuclides, and it has become a serious problem of concern globally. These non-biodegradable heavy metal ions from water tends to accumulate in the soil and living organisms and causes serious health hazards in humans. Thus, the finding of recyclable, water-stable MOFs, and multi-functional MOFs (hybrid MOFs) with superior adsorption capability have emerged as a novel material for the removal of heavy metal species (such as Cr(III)/Cr(VI), Cu(II), Hg(II), Cd(II), As(III)/As(V), Pb(II), radionuclides U(VI), Se(IV)/(VI), Cs(I) from aqueous solution. This chapter deals with the recent development of MOFs and their application in heavy metal removal from water.