Effect of Minocycline on Depressive Symptoms in Patients With Treatment-Resistant Depression
The findings of this randomized clinical trial suggest the need for more effective therapeutic interventions and biomarkers in this heterogeneous clinical condition.
Abstract
Key Points Question Does 6 weeks of minocycline treatment as add-on to standard antidepressant treatment reduce depressive symptoms in patients with treatment-resistant depression? Findings In this randomized clinical trial of 168 patients with treatment-resistant depression, 6 weeks of minocycline treatment did not show a statistically significant advantage compared with placebo on the overall course of depressive symptoms. Meaning The findings of this randomized clinical trial suggest the need for more effective therapeutic interventions and biomarkers in this heterogeneous clinical condition.