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The present invention relates to a method of producing reduced glutathione enriched rice wine, wherein the water used in the fermentation of wine brewing mineral water before fermentation stage, reduced glutathione is added after the extract was fermented rice wine brewing phase , extracted from waste rice wine yeast or yeast waste re wine fermentation, preferably, reduced glutathione extract further reduced glutathione content greater than 95% (by weight), reduced glutathione extract 0.01-0.1% (wt.) of the fermentation broth after the addition amount of wine fermentation stage of brewing, addition time after one week Rice wine fermentation stage. Also it provides the above method for producing reduced glutathione enriched wine. Rich production method according to the invention reduced glutathione rice wine cleverly designed, not only made the wine taste fresh, rich in trace minerals and reduced glutathione, and the whole process of environmental protection without adding more equipment, the overall efficiency is improved, suitable for application.