Wet‐Dog Shakes in Amygdaloid Methionine‐Enkephalin Kindling and Electrical Kindling
The role of wet-dog shakes in the kindling effect is investigated, comparing the mode of appearance of WDS in amygdaloid electrical kindling with that in methionine-enkephalin (ME) chemical kindling.
Abstract
The wet-dog shakes (WDS) behavior is a paroxysmal shudder of the head, neck and trunk and was described at first as a quantitative model of central 5-hydroxytryptamine (5-HT) activity. However, TRH, enkephalin, noradrenaline and dopamine were demonstrated to be related to WDS, independent of central 5-HT activity.2 WDS is known to be caused by amygdaloid or hippocampal electrical kindling;3 however, the relationship between WDS and kindling effect is not clarified. In the present study, we investigated the role of WDS in the kindling effect, comparing the mode of appearance of WDS in amygdaloid electrical kindling with that in methionine-enkephalin (ME) chemical kindling.