Immunology of febrile seizures Immunologia drgawek gorączkowych
Present studies suggest the correlation between immunological disorders and familial or sporadic incidence of febrile seizures and genetic polymorphism of interleukin 1β, 1α and IL-1 antagonist point to some associations between past febrian seizures and manifestation of temporal lobe epilepsy.
Abstract
Febrile seizures are the most common childhood neurological pathologies. They occur in 2–3% of children between 6 months and 5 years of age. A number of genetic mutations and also environmental factors contribute to their manifestation. The role of the immune system in the pathophysiology of febrile seizures has been raised since the end of 1980s. In children with febrile seizures the decreased production of immunoglobulins, particularly G2, was observed in brain with the normal serum level. In 1990 elevation of interleukin 1 beta in cerebrospinal fluid was found in the group with seizures as compared to the control group with the same infection but without febrile seizures. The association and significance of immunological disorders (increase of IL-1β, IL-6, IL-8, IL-1RA and decrease of CD4/ CD8 level) in the manifestation of febrile seizures and especially prolonged febrile seizures was observed in the literature particularly during the last decade. Present studies suggest the correlation between immunological disorders and familial or sporadic incidence of febrile seizures. The studies on genetic polymorphism of interleukin 1β, 1α and IL-1 antagonist point to some associations between past febrile seizures and manifestation of temporal lobe epilepsy.