Metabolic dysfunction and obesity‐related cancer: Beyond obesity and metabolic syndrome
A review of 129 studies that evaluated variable definitions of metabolic dysfunction in relation to obesity‐related cancer risk and mortality after a cancer diagnosis finds that metabolic dysfunction driven by obesity increases risk for developing at least 13 cancer types.
Abstract
Objectives: The metabolic dysfunction driven by obesity, including hyperglycemia and dyslipidemia, increases risk for developing at least 13 cancer types. The concept of “metabolic dysfunction” is often defined by meeting various combinations of criteria for metabolic syndrome. However, the lack of a unified definition of metabolic dysfunction makes it difficult to compare findings across studies. This review summarizes 129 studies that evaluated variable definitions of metabolic dysfunction in relation to obesity‐related cancer risk and mortality after a cancer diagnosis. Strategies for metabolic dysfunction management are also discussed.