Kindling: Changes of the Afterdischarge Threshold in the Primary and Secondary Sites during Kindling of Cats: II. A Study in Neocortical Kindling
Changes of the ADT in the primary kindled sites as well as secondary unstimulated sites in neocortical kindled cats are observed, consistent with a previous finding that the seizure susceptibility produced by limbic kindling is more persistent and potent than that of neocorticals kindling.
Abstract
We have recently demonstrated that the afterdischarge threshold (ADT) in the limbic foci rapidly decreases, not only in the primary focus but also in the remote brain regions, in the early process of acquisition of the limbic epileptogenesis and that the reduction of the ADT is closely related to the development of secondary epileptogenesis. In particular, the pyriform cortex acquires the neuronal hyperexcitability in limbic kindling.' However, changes of the ADT in the process of neocortical kindling have not been observed sufficiently. It is well known that limbic seizures are more intractable than neocortical seizures. This evidence is consistent with a previous finding that the seizure susceptibility produced by limbic kindling is more persistent and potent than that of neocortical kindling.2 In this study, we observed changes of the ADT in the primary kindled sites as well as secondary unstimulated sites in neocortical kindled cats.