Getting stress out of stressed‐out stress granules
5 Citations•2017•
P. Siwach, D. Kaganovich
The EMBO Journal
A direct link between misfolded proteins accumulating in Stress granules and the phase transition of these stress granules from liquid to solid is reported, providing a model connecting protein aggregation to stress granule dysfunction.
Abstract
Amyotrophic lateral sclerosis (ALS) pathology is linked to the aberrant aggregation of specific proteins, including TDP‐43, FUS, and SOD1, but it is not clear why these aggregation events cause ALS. In this issue of The EMBO Journal, Mateju et al (2017) report a direct link between misfolded proteins accumulating in stress granules and the phase transition of these stress granules from liquid to solid. This discovery provides a model connecting protein aggregation to stress granule dysfunction.