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The invention discloses a quantum dot synthesis device. The device comprises a precursor reaction area, a core reaction area, a core/shell reaction area for a core/shell reaction, and a storage container which are sequentially connected, each of above reaction areas includes at least one spiral reaction tube, the inner wall of every spiral reaction tube is provided with a passing groove having a direction opposite to the spiral direction and allowing reactants injected into the reaction tube to generate a bubbling effect due to friction, the front segment of every reaction area is coated with a heating zone, the rear segment of every reaction area is coated with a cooling zone, a plurality of injection ports are respectively arranged at the front ends of the reaction areas, a plurality of floating material discharge openings are respectively arranged at the rear end of the core reaction area and the rear end of the core/shell reaction area, and the front end of every reaction area is connected with a pressurizing device. The invention also discloses a quantum dot synthesis method. The device and the method improve the stability of quantum dots and the size uniformity of particle, and make the quantum dots have no defects, so the quantum efficiency is maximized, and the luminous efficiency and the sharpness are improved.