Molecular biology of the parathyroid hormone: biological actions
Inactivatin gmutations in these genes controlling the multi-step process ofcalcium homeostasis lead to hypocalcemic disorders, as outlined in accompanying articles.
Abstract
Parathyroid hormone (PTH); the principal parathyroid hormone receptor (PTH1R); a G protein-linked heptahelical membrane receptor; and a second heptahelical receptor, the calcium- sensing receptor (CaR) through a tightly-regulated endocrine feedback system together constitute the principal regulators of calcium homeostasis. The effectors of the calcium regulation are coordinated responses in target tissues.These responses as well as hormone biosynthesis, secretion and signaling are all under precise genetic control. Inactivatin gmutations in these genes controlling the multi-step process ofcalcium homeostasis lead to hypocalcemic disorders, as outlined in accompanying articles.