General aspects of the genetics of SLE
48 Citations•2007•
Benjamin Rhodes, T. Vyse
Autoimmunity
The current understanding of SLE genetics is outlined, in particular summarising the results of recent association studies, and several candidate genes with diverse immunological function are identified.
Abstract
The application of genetic techniques to the study of systemic lupus erythematosus (SLE) has identified candidate genes with diverse immunological function. There is a growing understanding that susceptibility to SLE is due to a complex interaction of multiple genes and environmental factors, and that many of these may be shared with other autoimmune diseases. In this first of a series of review articles we outline our current understanding of SLE genetics, in particular summarising the results of recent association studies.