The Viscosity Reduction Platform: Viscosity-reducing excipients for protein formulation

Abstract

Protein viscosity is one of the major obstacles in preparing highly concentrated protein formulations suitable for subcutaneous (subQ) injection. Highly viscous protein solutions would require a significant force to be applied to the syringe for injection. As a result, the patient could experience a considerable amount of pain. In many cases, injectability would not be possible.1,2 The Viscosity Reduction Platform: Viscosityreducing excipients for protein formulation