Fragile brains, ‘The Brain of the Elderly’

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Abstract

The authors invited future studies to confirm the possible link of POCD to irreversible brain damage and neuronal loss and to analyse the effects of anaesthetic agents on central neurotransmission. They reported no major contribution of hypotension and hypoxemia to POCD, without underestimating individual variation. The frailest patients were excluded based on mini mental status examination (MMSE) score. The study emphasised the importance of pre‐operative cognitive testing to differentiate a POCD from a pre‐existing cognitive impairment.[2,3]