Fifty years on: Serotonin and depression
25 Citations•2023•
S. Jauhar, P. Cowen, M. Browning
Journal of Psychopharmacology (Oxford, England)
In this narrative review, the evidence for the serotonin hypothesis of depression is summarized, focusing on psychopharmacology and molecular imaging, as well as systems-level neuroscience.
Abstract
It has been over 50 years since the original serotonin hypothesis was proposed by the British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the hypothesis. In this narrative review, we summarise the evidence for the serotonin hypothesis of depression, focusing on psychopharmacology and molecular imaging, as well as systems-level neuroscience.