Heterocyclic dihydropyrimidine compounds
Proposed compounds are inhibitors of calcium channel function being especially inhibitor of K v 1 subfamily of potential-overlapping K + -channels and especially inhibitors ofK v 1.5 that associated with super-rapid activating delayed cleaning K +-flow of I kur and can be used in treatment of arrhythmia and IKur -associated diseases.
Abstract
FIELD: organic chemistry, heterocyclic compounds, medicine. SUBSTANCE: invention relates to dihydropyrimidine compounds of the formula (I*): their enantiomers, diastereoisomers and pharmaceutically acceptable salts wherein X 1 , X 2 and X 3 in common with atoms to which they are added form ring of the formula: or ; R 1 represents hydrogen atom; R 2 , R 3* , R 4 , R 5 , R 6 and R 7 have values given in cl. 1 of the invention claim. Also, invention relates to separate dihydropyrimidine compounds. Proposed compounds are inhibitors of calcium channel function being especially inhibitors of K v 1 subfamily of potential-overlapping K + -channels and especially inhibitors of K v 1.5 that associated with super-rapid activating delayed cleaning K + -flow of I kur and can be used in treatment of arrhythmia and I kur -associated diseases. EFFECT: valuable medicinal properties of compounds. 15 cl, 589 ex