In this cohort study of 3124 adults, individuals at high genetic risk of obesity needed higher daily step counts to reduce the risk of obesity than those at moderate or low genetic risk.
Key Points Question Does the degree of physical activity associated with incident obesity vary by genetic risk? Findings In this cohort study of 3124 adults, individuals at high genetic risk of obesity needed higher daily step counts to reduce the risk of obesity than those at moderate or low genetic risk. Meaning These findings suggest that individualized physical activity recommendations that incorporate genetic background may reduce obesity risk.