Synthesis of dopastin, a dopamine β-hydroxylase inhibitor of microbial origin
5 Citations•1973•
M. Ohno, H. Iinuma, N. Yagisawa
Journal of The Chemical Society, Chemical Communications
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Abstract
Dopastin has been synthesised from L-valinol by an 8-step procedure, in which the key stage involves oxaziran formation followed by hydrolysis with Dowex 50W, with retention of the absolute configuration of the starting material in the final product.