Generation of genetically modified antigen

Abstract

Use dominant negative allele of a mismatch repair gene human can create hypermutation possible cells and organisms. By these genes are introduced into cells and transgenic animals, changes in new cell lines animals with novel and useful properties, can be efficiently prepared than due to natural mutation rate. These methods generate genetic diversity in a gene encoding a therapeutic agent is useful for the production of altered polypeptides with enhanced antigen and immunogenic activity. These methods further is useful for producing effective vaccines.