HLA-DRβ2 and IgM Rheumatoid Factor (RF) Positive Rheumatoid Arthritis (RA)
88 Citations•1988•
G. Haberhauer, P. Peichl
International Journal of Immunopathology and Pharmacology
The results confirm the hypothesis that the HLA-DRβ2 chain gene is closer related to the disease susceptibility of seropositive RA than the DRβ1 chain gene (DR4) and find a significant increase of Hla-DRw53 in patients with RF positive RA.
Abstract
48 patients suffering from classic erosive RA with conditions persisting for more than 6 years were examined together with 69 healthy control subject with regard to associations to supertypic HLA-D specificities. We found a significant increase of HLA-DRw53 in patients with RF positive RA (22/31 pat. = 71%,Chi2 = 13.2, p<0.01). Our results confirm the hypothesis that the HLA-DRβ2 chain gene is closer related to the disease susceptibility of seropositive RA than the DRβ1 chain gene (DR4).