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Reversible and pH-dependent adsorption of vanillin by HS zeolite Y. Negligible adsorption of caffeic acid by HS zeolite Y at any pH. Irreversible and pH-dependent adsorption of sulfamethoxazole by HS zeolite Y. Evidence of a vanillinsulfamethoxazole adduct into the zeolite pores. Guest-guest interactions into zeolite pores and computation of stabilization energy. a r t i c l e i n f o Article history: Received 26 August 2015 Received in revised form 23 March 2016 Accepted 4 April 2016 Handling Editor: Xiangru Zhang