Sulfinylation of heterocyclic compound

Abstract

PURPOSE: To provide a new sulfinylation process of a heterocyclic compound wherein the difficulty of oxidation and the toxicity of reactants are avoided. CONSTITUTION: A compound of the formula: RS(O)X [wherein R is a 1-4C, linear or branched alkyl substituted by one or more halogens; and X is a halogen, OH, NR 2 R 3 (wherein R 2 and R 3 are each a 1-4C alkyl or 1-4C haloalkyl) or aryloxy (wherein the aryl portion is preferably phenyl which is optionally substituted by one or more halogens, 1-4C alkyl or 1-4C haloalkyl)] is allowed to react with a heterocyclic compound chosen from the group consisting of pyrrole, pyrazole, imidazole, oxazole, isoxazole, thiazole, isothiazole and triazole to sulfinylate this heterocyclic compound. This process is especially suitable when the heterocyclic compound is a compound of formula I or formula II [wherein R 1 is a halogen (preferably F), alkyl or haloalkyl (preferably CF 3 or SF 5 )]. COPYRIGHT: (C)1995,JPO