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This chapter examines the extent to which cross-disciplinary understandings of resilience support the development and application of multisystemic resilience approaches based on evidence in current literature. It focuses on how systems thinking—especially complex adaptive systems—has informed the evolution of social-ecological systems resilience analysis and the extent to which this provides an example of multisystemic resilience. It reviews some of the underlying concepts and principles in the field and the boundary-pushing areas of recent research. Finally, it identifies how systemic resilience analysis can make a difference in understanding key global challenges and suggests ways forward for development of a multisystemic resilience field.