A general model for genetic recombination.
733 Citations•1975•
M. Meselson, C. Radding
Proceedings of the National Academy of Sciences of the United States of America
A general model is proposed for genetic recombination, which proposes the hypothesis that recombination is initiated by a single-strand (or asymmetric) transfer, which may, after isomerization, become a two-stranded exchange.
Abstract
A general model is proposed for genetic recombination. Its essential new feature is the hypothesis that recombination is initiated by a single-strand (or asymmetric) transfer, which may, after isomerization, become a two-strand (or symmetric) exchange. The likelihood of this transition from asymmetric to symmetric strand exchange determines certain characteristic features of recombination in any particular organism.