Gut microbiota and obesity
impact of gut microbiota composition and changes in metabolite profile on the obesity pathogenesis and related metabolic disorders and such therapeutic microbiota’s agents as antibiotics, pre-, auto- and probiotics, as well as fecotransplantation are examined.
Abstract
The global prevalence of obesity has almost tripled since the end of the last century. Excess body weight is responsible for nearly 2.8 million deaths each year due to complications. Many studies support both a genetic predisposition and the role of the gut microbiome in obesity’s development. The review is highlight recent scientific advances in understanding the relationships between the gut microbiome, obesity, and comorbidities for cause-and-effect relationships. It examines impact of gut microbiota composition and changes in metabolite profile on the obesity pathogenesis and related metabolic disorders. The article also discusses such therapeutic microbiota’s agents as antibiotics, pre-, auto- and probiotics, as well as fecotransplantation. Key words: obesity, microbiota, metabolites, children, short-chain fatty acids