The Chemistry of Organic Contrast Agents in the NIR-II Window.
This review summarized recently developed organic luminescent and photoacoustic materials, ranging from small molecules to conjugated polymers, and elucidated the challenges and prospective of these NIR-II organic dyes for potential clinical applications.
Abstract
Optical imaging, especially fluorescence and photoacoustic imaging, possesses non-invasiveness, high spatial and temporal resolution, and high sensitivity, etc., compared to positron emission tomography (PET) or magnetic resonance imaging (MRI). Due to the merits from the second near infrared (NIR-II) window imaging, like deeper penetration depth, high signal-to-noise ratio, high resolution, and low tissue damage, researchers devote great efforts to develop contrast agents with NIR-II absorption or emission. In this review, we summarized recently developed organic luminescent and photoacoustic materials, ranging from small molecules to conjugated polymers. Then, we systematically introduced engineering strategies and their imaging performance, classified by the skeleton cores. Finally, we elucidated the challenges and prospective of these NIR-II organic dyes for potential clinical applications. We hope our summary can inspire further development of NIR-II contrast agents.