[Advances in clustered regularly interspaced short palindromic repeats--a review].
1 Citations•2011•
Lili Wang, Jin He, Jieping Wang
Wei sheng wu xue bao = Acta microbiologica Sinica
The structure, diversity, mechanism of interference and self versus non-self discrimination of CRISPR systems are reviewed and the potential applications of this novel interference system are discussed.
Abstract
The recently discovered Clustered Regularly Interspaced Short Palindromic Repeat (CRISPRs) can protect bacteria and archaea with adaptive and heritable defense systems against the invasion of phage- and plasmid- associated mobile genetic elements. Here, we review the structure, diversity, mechanism of interference and self versus non-self discrimination of CRISPR systems. We also discuss the potential applications of this novel interference system.