It is shown that leptin prevents CRP from reducing body weight, and this results implies that leptin-like signals in the gut may be responsible for weight loss in chronically undernourished people.
![][1] CRP prevents leptin from reducing body weight. ZHAO/MACMILLAN Leptin always seemed a bit too good to be true. Why would our chronically undernourished ancestors have evolved a hormone for weight loss? Now, Ke Chen, Allan Zhao (University of Pittsburgh, PA), and colleagues