Animal models of Obsessive-Compulsive Disorder (OCD)
Researches and studies by using animal models indicate the role of serotonin neurotransmitter particularly 5-HT2c receptor, Dopamine neurotransmitter, particularly D1 and D2 receptors and at the less level therole of NMDA receptor of Glutamate neurotransmitter in pathology of OCD disorder.
Abstract
Treatment developments, brain imaging studies and results of pharmacological researches elicit revision of related pathological theories to Obsessive-compulsive disorder (OCD) and new research patterns. One of the important and alluring new research patterns under neurobiological approach corresponding to pathology and treatment of obsessive-compulsive disorder (OCD) are animal models which are used in this disorder. Insomuch, many endeavors have been applied in order to expand animal models of OCD during recent 30 years. In the hope of, increase our understanding and knowledge about pathology as well as treatment of this disorder. By considering the methodology of developing obsessive behaviors in animals, OCD animal models are divided into three classifications of behavioral, pharmacological and genetic. Researches and studies by using different animal models indicate the role of serotonin neurotransmitter particularly 5-HT2c receptor, Dopamine neurotransmitter particularly D1 and D2 receptors and at the less level the role of NMDA receptor of Glutamate neurotransmitter in pathology of OCD disorder