A psoriasis és az oxidatív stressz | Psoriasis and oxidative stress
The role of oxidative stress in the development of psoriasis and its complications through several well studied biomarkers is discussed and an increased risk of inflammatory bowel disease, cardiovascular disease and certain types of cancer is revealed.
Abstract
Absztrakt A psoriasis hazankban es vilagviszonylatban is a leggyakrabban előfordulo bőrbetegsegek egyike. Jelentőseget hangsulyozza a gyakran elethossziglan fennallo plakkok okozta fajdalom, mozgaskorlatozottsag es a psziches terheles eletminősegre gyakorolt hatasa. Szovődmenyeit tekintve a nemegyszer maradando karosodasokat okozo arthritis psoriatican tul, a psoriasisos betegek eseteben nagyobb cardiovascularis kockazattal kell szamolni, gyakrabban alakulnak ki gyulladasos belbetegsegek es bizonyos daganatok. Az exogen es endogen tenyezők okozta oxidativ stressz es a genetikai prediszpozicio hozzajarulhat a keratinocytak hiperproliferaciojahoz es abnormalis differencialodasahoz, ezaltal a psoriasis kialakulasahoz, illetve fenntartasahoz. A nagyfoku oxidativ stressz felelős lehet tovabba a psoriasis szovődmenyeinek megjeleneseert. Jelen kozlemenyben, rovid patofiziologiai attekintes utan, nehany jol ismert biomarker (aszimmetrikus dimetilarginin, malonilaldehid, szuperoxid dizmutaz, katalaz) segitsegevel a szerzők bemutatjak az oxidativ stressz szerepet a psoriasis es szovődmenyeinek kialakulasaban. Orv. Hetil., 2016, 157(45), 1781–1785. | Abstract Psoriasis is among the most common dermatological diseases worldwide. Its significance is emphasized by adverse effects on quality of life, caused by chronic pain, physical and psychical disability due to psoriatic plaques. Besides the development of psoriatic arthritis, which often causes permanent joint damage, former studies revealed an increased risk of inflammatory bowel disease, cardiovascular disease and certain types of cancer. Genetic predisposition and oxidative stress caused by exogenous and endogenous factors can contribute to abnormal differentiation and hyperproliferation of keratinocytes, accordingly the development and maintenance of psoriasis. Moreover, excessive oxidative stress can be responsible for the onset of psoriasis complications. After a brief pathophysiological summary the authors discuss the role of oxidative stress in the development of psoriasis and its complications through several well studied biomarkers (asymmetric dimethylarginine, malondialdehyde, superoxide dismutase, catalase). Orv. Hetil., 2016, 157(45), 1781–1785.