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A depression relapse prevention programme improved adherence to medication and depressive symptoms but did not decrease relapses
In primary care patients with major recurrent depression or chronic depression, does a relapse prevention programme improve adherence to medication and decrease symptoms and relapses?
Abstract
(2001) Arch Gen Psychiatry 58, 241. Katon W, Rutter C, Ludman EJ . , et al. . A randomized trial of relapse prevention of depression in primary care. . Mar; . : . –7 . [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] QUESTION: In primary care patients with major recurrent depression or chronic depression, does a relapse prevention programme improve adherence to medication and decrease symptoms and relapses? Randomised (allocation concealed*), blinded (outcome assessors)*, controlled trial with 12 months of follow up. 4 primary care clinics in Puget Sound, Washington, USA. 386 patients who were 18–80 years of age (mean age 46 y, 74% women); had a diagnosis of depression or anxiety, and a recent antidepressant prescription (no previous prescriptions in the past 120 days); and were considered to be at high risk of relapse (<4 DSM-IV major depressive symptoms and a history of ≥3 episodes of major depression or dysthymia, or 4 residual depressive symptoms but a mean 20 item Hopkins Symptom Checklist [SCL-20] score of <1.0 and a history of major depression or dysthymia). Exclusion criteria included a risk of alcoholism, pregnancy or lactation, currently seeing a psychiatrist, or recent use of … [1]: {openurl}?query=rft.jtitle%253DArchives%2Bof%2BGeneral%2BPsychiatry%26rft.stitle%253DArch%2BGen%2BPsychiatry%26rft.issn%253D0003-990X%26rft.aulast%253DKaton%26rft.auinit1%253DW.%26rft.volume%253D58%26rft.issue%253D3%26rft.spage%253D241%26rft.epage%253D247%26rft.atitle%253DA%2BRandomized%2BTrial%2Bof%2BRelapse%2BPrevention%2Bof%2BDepression%2Bin%2BPrimary%2BCare%26rft_id%253Dinfo%253Adoi%252F10.1001%252Farchpsyc.58.3.241%26rft_id%253Dinfo%253Apmid%252F11231831%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1001/archpsyc.58.3.241&link_type=DOI [3]: /lookup/external-ref?access_num=11231831&link_type=MED&atom=%2Febmental%2F4%2F4%2F113.atom [4]: /lookup/external-ref?access_num=000167339600005&link_type=ISI