Findings suggest that some individuals experience more adverse effects after COVID-19 vaccination, but serious adverse effects are rare.
Key Points Question What factors are associated with adverse effects after COVID-19 vaccination? Findings In an online cohort study including 19 586 adults who received a COVID-19 vaccination, the factors most strongly associated with adverse effects were full vaccination dose, brand of vaccine, younger age, female sex, and having had COVID-19 before vaccination. Allergic reaction or anaphylaxis was reported in 0.3% of participants after partial vaccination and 0.2% of participants after full vaccination. Meaning These findings suggest that some individuals experience more adverse effects after COVID-19 vaccination, but serious adverse effects are rare.