Blood-based biomarkers for Alzheimer’s disease
New small-molecule modulators of the Hedgehog signalling pathway are identified, which is known to drive tumorigenesis and GPR39 is a new component in Hedgehog signalling, and the inhibitors will be useful to study this receptor.
Abstract
Bassilana et al. identified new small-molecule modulators of the Hedgehog signalling pathway, which is known to drive tumorigenesis. The series of cyclohexyl-methyl aminopyrimidine compounds acted downstream of the Smoothened protein, and target identification studies revealed that they stimulated the orphan G protein-coupled receptor GPR39, which then signals to GLI transcription factors to block signalling. So GPR39 is a new component in Hedgehog signalling, and the inhibitors will be useful to study this receptor.