Alzheimer's disease
The clinical features of a case of Alzheimer’s disease and a histochemical and morphologic analysis of a cerebral biopsy are reported and the histochemical technics to be described are being used as a laboratory routine for extensive mappings of the normal human brain.
Abstract
THIS AHTICLE REPORTS the clinical features of a case of Alzheimer’s disease and a histochemical and morphologic analysis of a cerebral biopsy. In view of the provocative nature of the observations, it was very fortunate that ample material was available for histochemical studies within thirty minutes after it was removed from the patient, thus providing ideal material for histochemistry. The histochemical technics to be described are being used as a laboratory routine for extensive mappings of the normal human brain; their reliability has been well established.’ All of the findings which did not require fresh material were compared with numerous cases of Alzheimer’s disease from the collections of the Laboratory of Neuropathology of the University of Michigan.