DNA Methylation: Molecular Biology and Biological Significance
The role of DNA methylation in the regulation of plant expression and its significance for the activation or silencing of specific genes is investigated.
Abstract
A chronicle of DNA methylation (1948-1975).- Major techniques to study DNA methylation.- Methylation of cytosine influences the DNA structure.- Methylation of DNA in prokaryotes.- Structure, function and regulation of mammalian DNA methyltransferase.- Regulation of the de novo methylation.- Effect of DNA methylation on the binding of vertebrate and plant proteins to DNA.- CpG Islands.- DNA methyltransferases and DNA site-specific endonucleases encoded by chlorella viruses.- Control of DNA methylation in fungi.- The role of DNA methylation in the regulation of plant expression.- Pattern of de novo methylation and promoter inhibition: studies on the adenovirus and the human genome.- DNA methylation and retrovirus expression.- Effect of DNA methylation on dynamic properties of the helix and nuclear protein binding in the H-ras promoter.- DNA methylation and embryogenesis.- X chromosome inactivation and DNA methylation.- DNA methylation: Its possible functional role in developmental regulation of human globin gene families.- DNA methylation, chromatin structure and the regulation of gene expression.- Steroid hormone-dependent changes in DNA methylation and its significance for the activation or silencing of specific genes.- Epigenetic inheritance based on DNA methylation.- DNA methylation and genomic imprinting in mammals.- DNA methylation and cancer.- The repair of 5-methylcytosine deamination damage.- Gene methylation patterns and expression.