Top Research Papers on Bipolar Disorder

Screening in high-risk groups of persons with depression, anxiety disorders, and substance use disorders-conditions frequently seen by primary care clinicians for bipolar disorder is indicated.

An overview of the clinical features, diagnostic subtypes, and major treatment modalities available to treat people with bipolar disorder are provided, highlighting recent advances and ongoing therapeutic challenges.

Bipolar disorder is characterized by episodes of mania, hypomania, and depression and recurrences of manic or depressive symptoms are common.

A narrative review summarizes common and distinctive findings from genetics, neuroimaging, cognition and clinical course that may help to solve the ethiopathogenetic puzzle of schizophrenia and bipolar disorder.

Bipolar disorder and substance-induced mood disorders can acutely present in an identical manner; differentiating between the 2 can be very difficult, if not impossible, when mood lability is manifested.

The view that many (although far from all) individuals with bipolar disorder are competent to consent to a wide variety of things when they are in a manic state is defended.

Mental health clinicians can support primary care physicians in the evaluation and treatment of patients with bipolar disorder (BD), and psychotherapy, such as cognitive behavioral therapy and psychoeducation on management strategies, can be a useful adjunct therapy.

Life expectancy is reduced by approximately 12 to 14 years in people with bipolar disorder, with a 1.6-fold to 2-fold increase in cardiovascular mortality occurring a mean of 17 years earlier compared with the general population.

Clinical heterogeneity of bipolar disorder is underpinned by etiological heterogeneity linked to components of differentiating genetic liability that reflects the symptomatology of the cognate disorders.

Patients with bipolar disorder should be assessed continually for risk of suicide because they are at high risk and their suicide attempts tend to be successful.

After February 2022, the situation in the Arctic begins to acquire some features of a hybrid war, which speak of new negative trends taking place in the region. Many large European and Asian companies from unfriendly countries have left or declared their intention to leave economic projects in the Russian Arctic. Interaction with the foreign scientific community in the field of Arctic research has almost ceased. The well-established algorithm of the Arctic Council’s activities was violated (in March, the participation of Western countries in the events of the chairmanship of the Russian Federa...

The aim of the narrative review was to illustrate the numerous intersections between BSD and neurological disorders from a clinical-biological point of view and the underlying predisposing factors, to guide future diagnostic and therapeutical research in the field.

It is intended to emphasize that, although rare, the diagnosis of mania after stroke should not be forgotten, and most important, one should be aware of the recurrence of affective episodes just as in non-medical-caused bipolar disorder.

The aim of this article is to distinguish between the different challenges that bipolar patients must overcome, whether it concerns working hours, teamwork, or the choice of profession.

This review aims to highlight the most effective psychotherapies used in the treatment of bipolar disorder and suggests that interpersonal social rhythm therapy, psychoeducation, cognitive-behavioral therapy, family-focused therapy and mindfulness therapy have a constructive role to play as adjunctive models of psychotherapy in the management of bipolar disorder.

Climate changes have been very marked in last years and their consequences on mental health are becoming increasingly known, taking this into account could contribute to the development of a more appropriate and targeted care for patients suffering from psychiatric disorders, and in particular in the case of bipolar disorder.

The concerns and advantages of including these less-established manifestations of bipolar disorders in the diagnostic thinking are discussed here, and the utility and drawbacks of the current diagnostic protocols are considered.

This study aimed to assess the capabilities of ChatGPT (Chat Generative Pre‐Trained Transformer) in generating informative content related to bipolar disorders and to explore its creativity in generating topic‐related songs.

Regardless of which of the mechanisms described here plays a primary or secondary role in the pathophysiology of bipolar disorder, all of these interact to worsen clinical outcomes for patients.

OABD forms a more complex subgroup of bipolar disorder, with an increased risk of cognitive deficits, physical comorbidities, impaired psychosocial functioning, and premature death.

Bipolar disorder (BD) is a mental health condition characterized by significant mood swings. These mood fluctuations can profoundly impact various aspects of an individual’s life, including their work functions. Despite the critical nature of understanding how BD affects workplace dynamics, there is a notable lack of research focusing on this area, especially within the context of Saudi Arabia. This gap in literature underscores the need for a detailed exploration of the experiences of Saudi employees living with BD. The primary goal of this study is to delve into the lived experien...

The results show that schizophrenia patients scored higher on pareidolia measures than both healthy controls and patients with bipolar disorder, in agreement with prior findings on more impaired cognitive processes in schizophrenia than in bipolar patients.

Childhood onset bipolar disorder (CO-BD) presents a panoply of difficulties associated with early recognition and treatment. CO-BD is associated with a variety of precursors and comorbidities that have been inadequately studied, so treatment remains obscure. The earlier the onset, the longer is the delay to first treatment, and both early onset and treatment delay are associated with more depressive episodes and a poor prognosis in adulthood. Ultra-rapid and ultradian cycling, consistent with a diagnosis of BP-NOS, are highly prevalent in the youngest children and take long periods of time and...

Doctors should consider bipolar disorder in any patient presenting with depression, and patients and their support systems should be educated about the chronic nature of this illness, possible relapse, suicidality, environmental triggers, and the effectiveness of early intervention to reduce complications.

It was found that personality disorders as a comorbid disorder in type I bipolar disorder are less common than in type II bipolar disorder, and gender differences were found in the incidence of anxiety-phobic spectrum and substance use disorders in bipolar disorder.

A number of deficits have been consistently identified in both adolescent and adult populations that perhaps reflect disease traits and future research needs to focus on these and employ multimodal tests in pristine patient groups, with a view to identifying reliable biomarkers.

Existing date support the idea that a low level of magnesium and zinc play a role in pathogenesis of BD, but the assertion of a definite beneficial role of the association ofnesium and zinc with mood modulators in BD therapy requires more clinical studies.

The identified associations of clozapine use with particular clinical features call for vigilance in personalized clinical monitoring so as to optimize clinical outcomes of BD patients and to limit risks of adverse effects of polytherapy.

There may be a link between puberty and the onset of BD in females with comorbid PMDD and BD, marked by a shortened gap between the onsetof BD and menarche, and in terms of neurobiology, comorbrid BD and PMDD may have unique structural and functional neural correlates.

The development of guidelines for the assessment of psychosocial functioning helps to facilitate a better understanding of OABD and can lead to better tailored interventions to improve the clinical outcomes of this population.

New evidence of association between bipolar disorder (BD) and ASD is summarized and caution with SSRI-treatment among people with ASD is crucial as the treatment can potentially trigger a mood episode of an underlying BD.

Clinicians should be aware of complications when prescribing in bipolar disorders comorbidity and first line mood stabilizers such as valproate and lithium and new generation antipsychotic quetiapine seem to be the leading options.

Considering the shared symptoms such as impulsive and dangerous behaviors, in patients with only one disease, misdiagnosis is a common phenomenon and it may be useful to recognize the co-occurrence of the disorders and better characterize the patient with ASPD and BD evaluating all dysfunctional aspects and their influence on core symptoms

Recent work has begun to examine the link between motivation for specific emotions and psychopathology. Yet research on this topic to date has focused primarily on depression. To understand patterns of motivation for emotions within and across affective disorders, we assessed motivation for emotions in adults at increased risk for and diagnosed with bipolar disorder (BD). We focused on motivation for negative (i.e., sadness) and positive (i.e., happiness) emotions and for emotional instability using self-report and behavioral measures. Both increased BD risk and diagnosis of BD were associated...

The preliminary findings suggest that dietetic approaches might be included as part of BD treatment, and considering the high risk of metabolic disorders in individuals with BD, they should be encouraged to choose healthy dietary lifestyles, including daily intake of fruits, vegetables, seafood and whole grains.

In the scientific review, a systematic review of the literature in PubMed and Google was conducted, epidemiological data were presented, issues of systematization and pharmacotherapy were considered, including modern meta-analyses and recommendations, including the effectiveness and safety of antipsychotic therapy.

There is no conclusive cognitive profile characterizing bipolar disorder, but cognitive functioning is of great importance in understanding occupational functioning in bipolar disorder and it is shown that changes in cognitive functioning over time do not differ between patients and healthy controls.

Differences in etiological agents between BD and other mental disorder lied in difference in expression of allele and environmental factors, such as childhood trauma or stressful environment, which could help researchers and psychiatrists to diagnose and treat the patients.

The rate of comorbid attention-deficit hyperactivity disorder and bipolar disorder far exceeds chance if the two are independent conditions, and management implications are considered.

The results suggest impulsivity may be a trait feature of BD, however longitudinal cohort studies are required to confirm whether elevated impulsivity is present before illness onset, and whether cognitive interventions are beneficial in improving impulsivity in BD.

Patients with BD had a high degree of impulsivity outside the critical period compared to healthy individuals, and this impulsivity could be a vulnerability marker to the risk of early onset of the disease or therisk of its relapse.

An electron directional physiological explanation for the observed brain dysfunction of schizophrenia and bipolar disorder patients is provided to indicate the potential abnormalities of SCH patients and BD patients in distributing neural resources and influencing opportune transitions between different states of activity.

BACKGROUND Bipolar disorder (BD) is a severe psychiatric disorder characterized by mood swings. Psychosocial interventions, such as psychoeducation, play an essential role in promoting social rehabilitation and improving pharmacological treatment. AIM To investigate the role of psychoeducation in BD. METHODS A systematic review of original studies regarding psychoeducation interventions in patients with BD and their relatives was developed. A systematic literature search was performed using the Medline, Scopus, and Lilacs databases. No review articles or qualitative studies were included in th...

This chapter reviews the genetic epidemiology, molecular genetics, and genetic modelling studies of bipolar disorder and anticipates some future research directions of relevance to clinical care.

The low amount of explained phenotypic variance highlights the need for further large-scale investigations, especially among non-European populations, to achieve a more complete understanding of the genetic architecture of bipolar disorder and the missing heritability.

A commentary on the author’s work on testosterone, summarize the literature onosterone, bipolar disorder, and suicide, and encourage future research on this poorly studied topic is provided.

The aim of this review was to provide an up‐to‐date overview of research on the efficacy, tolerability and cognitive effects of electroconvulsive therapy, transcranial magnetic stimulation, transranial direct current stimulation (tDCS), magnetic seizure therapy (MST), deep brain stimulation (DBS) and vagus nerve stimulation (VNS).

Clinicians are updated on the recognition, diagnosis and management of bipolar disorder in light of recent research to update clinicians on the strongest evidence base for lithium and atypical antipsychotics.

This issue of Psychiatric Annals is focused on the lack of systematic treatment information for the increasingly recognized disorder of childhood-onset bipolar illness, and the multiple factors appear to be converging to cause and continue this shortfall.

This chapter provides an overview of the most current research, causes, signs, symptoms, and diagnostic criteria of bipolar I and bipolar II disorder and cyclothymia.