Top Research Papers on Bipolar Disorder

Trusted information on what bipolar disorder and on the depression and mania periods, and links to trusted resources

People with the disorder may have an onset of an episode in association with emotional and physical stresses, a lack of sleep, the loss of an important relationship, or drug and alcohol use, changes in routine or excessive stimulation may predispose to a manic episode.

This JAMA Patient Page describes bipolar disorder: diagnosis, treatment, and prognosis.

People with bipolar disorder experience both dramatic "highs," called manic episodes, and "lows," called depressive episodes, which can last from hours to weeks, and many people have no symptoms between episodes.

People with bipolar disorder experience both dramatic "highs," called manic episodes, and "lows," called depressive episodes. These episodes can last from hours to weeks, and many people have no symptoms between episodes. Manic episodes are characterized by increased energy and activity, irritability, restlessness, an inability to sleep, and reckless behavior. Depressive episodes are marked by low energy and activity, a feeling of hopelessness, and an inability to perform everyday tasks. People with bipolar disorder often have repeated thoughts of death and suicide, and they have a much greate...

Current best practice in the diagnosis and management of bipolar disorder is summarised, signposting areas of uncertainty.

This chapter aims to provide a critical overview of psychopathological, sociodemographic, and neurobiological features to help clinicians properly distinguish unipolar and bipolar depression.

It is apparent that the rate of misdiagnosis of bipolar disorder is very high, particularly when attempting to differentiate the depressive phase of the condition from unipolar major depression.

In this Primer on text, leading international authors explore aspects of clinical presentation epidemiology, etiology, neurobiology, and treatment of bipolar disorder.

This overview of bipolar disorder offers six scholarly reviews of the condition, accompanied by 122 brief commentaries from international experts. The result is a stimulating and comprehensive account of recent research, set in the context of a consensus about the findings. The commentaries include many enlightening and imaginative ideas. Akiskal’s introductory review, on the diagnosis and classification of bipolar disorders, is perhaps his most articulate and convincing exposition of the concept of the ‘bipolar spectrum’ of conditions. These he subdivides into eight types, that can be recogni...

Bipolar disorder is a potentially lifelong and disabling condition that affects 1 per cent of the adult population and can vary in length and frequency.

Screening in high-risk groups of persons with depression, anxiety disorders, and substance use disorders-conditions frequently seen by primary care clinicians for bipolar disorder is indicated.

People with bipolar disorder experience both dramatic "highs," called manic episodes, and "lows," called depressive episodes, which can last from hours to weeks, and many people have no symptoms between episodes.

This systematic review presents information relating to the effectiveness and safety of the following interventions: antidepressants, carbamazepine, chlorpromazine, clonazepam, cognitive therapy, education, family-focused psychoeducation, gabapentin, haloperidol, lamotrigine, lithium, olanzapine, psychological treatments, quetiapine and risperidone.

An overview of genome-wide significant loci for bipolar disorder (polygenetics), potential biomarkers, dysregulation of immuno-inflammatory mechanisms, and the role of neuroplasticity in the pathophysiology and treatment of BD are reviewed.

Bipolar disorder is currently undergoing a diagnostic epidemic. This is because proponents of a broad bipolar spectrum, who can be called “bipolar imperialists” see latent bipolarity in a wide spectrum of other diagnoses. Thus bipolar disorders are being overdiagnosed in patients who are depressed, in patients who have affective instability related to personality disorders, and in children who mainly present with irritability. None of these patients demonstrate manic episodes or the hypomanic episodes required to diagnose bipolar-II. There are no biological markers to support this expansion of...

This chapter provides an overview of the most current research, causes, signs, symptoms, and diagnostic criteria of bipolar I and bipolar II disorder and cyclothymia.

This brochure talks about bipolar mood disorder, its symptoms and possible causes, treatment options and where to go for help.

People with bipolar disorder experience both dramatic "highs," called manic episodes, and "lows," called depressive episodes, which can last from hours to weeks, and many people have no symptoms between episodes.

Bipolar disorder is a common, recurrent, and severe psychiatric disorder that affects 1% to 3% of the US population and several medications are now available to treat the acute mood episodes and to prevent further episodes with maintenance treatment.