Top Research Papers on Bipolar Disorder

Bipolar disorder and substance-induced mood disorders can acutely present in an identical manner; differentiating between the 2 can be very difficult, if not impossible, when mood lability is manifested.

Patients with bipolar disorder should be assessed continually for risk of suicide because they are at high risk and their suicide attempts tend to be successful.

The concerns and advantages of including these less-established manifestations of bipolar disorders in the diagnostic thinking are discussed here, and the utility and drawbacks of the current diagnostic protocols are considered.

A number of deficits have been consistently identified in both adolescent and adult populations that perhaps reflect disease traits and future research needs to focus on these and employ multimodal tests in pristine patient groups, with a view to identifying reliable biomarkers.

This issue of Psychiatric Annals is focused on the lack of systematic treatment information for the increasingly recognized disorder of childhood-onset bipolar illness, and the multiple factors appear to be converging to cause and continue this shortfall.

A preponderance of data support the hypothesis that pediatric BD is continuous with adult BD, and prospective studies incorporating phenomenological and biological assessment are needed to decisively address this issue.

It is apparent that the rate of misdiagnosis of bipolar disorder is very high, particularly when attempting to differentiate the depressive phase of the condition from unipolar major depression.

Bipolar disorder is a common, recurrent, and severe psychiatric disorder that affects 1% to 3% of the US population and several medications are now available to treat the acute mood episodes and to prevent further episodes with maintenance treatment.

This chapter aims to provide a critical overview of psychopathological, sociodemographic, and neurobiological features to help clinicians properly distinguish unipolar and bipolar depression.

An overview of genome-wide significant loci for bipolar disorder (polygenetics), potential biomarkers, dysregulation of immuno-inflammatory mechanisms, and the role of neuroplasticity in the pathophysiology and treatment of BD are reviewed.

Screening in high-risk groups of persons with depression, anxiety disorders, and substance use disorders-conditions frequently seen by primary care clinicians for bipolar disorder is indicated.

People with bipolar disorder experience both dramatic "highs," called manic episodes, and "lows," called depressive episodes, which can last from hours to weeks, and many people have no symptoms between episodes.

Bipolar disorder is a potentially lifelong and disabling condition that affects 1 per cent of the adult population and can vary in length and frequency.

Natalie notices that her best friend Jean has been exhibiting unusual, uncharacteristic behavior since the start of summer vacation, and has barely seen Jean out for this entire past week.

Bipolar disorder is currently undergoing a diagnostic epidemic. This is because proponents of a broad bipolar spectrum, who can be called “bipolar imperialists” see latent bipolarity in a wide spectrum of other diagnoses. Thus bipolar disorders are being overdiagnosed in patients who are depressed, in patients who have affective instability related to personality disorders, and in children who mainly present with irritability. None of these patients demonstrate manic episodes or the hypomanic episodes required to diagnose bipolar-II. There are no biological markers to support this expansion of...

People with bipolar disorder experience both dramatic "highs," called manic episodes, and "lows," called depressive episodes, which can last from hours to weeks, and many people have no symptoms between episodes.

This systematic review presents information relating to the effectiveness and safety of the following interventions: antidepressants, carbamazepine, chlorpromazine, clonazepam, cognitive therapy, education, family-focused psychoeducation, gabapentin, haloperidol, lamotrigine, lithium, olanzapine, psychological treatments, quetiapine and risperidone.

People with bipolar disorder experience both dramatic "highs," called manic episodes, and "lows," called depressive episodes, which can last from hours to weeks, and many people have no symptoms between episodes.

People with bipolar disorder experience both dramatic "highs," called manic episodes, and "lows," called depressive episodes, which can last from hours to weeks, and many people have no symptoms between episodes.

People with bipolar disorder experience both dramatic "highs," called manic episodes, and "lows," called depressive episodes, which can last from hours to weeks, and many people have no symptoms between episodes.

Clinicians are updated on the recognition, diagnosis and management of bipolar disorder in light of recent research to update clinicians on the strongest evidence base for lithium and atypical antipsychotics.

People with bipolar disorder experience both dramatic "highs," called manic episodes, and "lows," called depressive episodes, which can last from hours to weeks, and many people have no symptoms between episodes.

Current best practice in the diagnosis and management of bipolar disorder is summarised, signposting areas of uncertainty.

This overview of bipolar disorder offers six scholarly reviews of the condition, accompanied by 122 brief commentaries from international experts. The result is a stimulating and comprehensive account of recent research, set in the context of a consensus about the findings. The commentaries include many enlightening and imaginative ideas. Akiskal’s introductory review, on the diagnosis and classification of bipolar disorders, is perhaps his most articulate and convincing exposition of the concept of the ‘bipolar spectrum’ of conditions. These he subdivides into eight types, that can be recogni...

In this Primer on text, leading international authors explore aspects of clinical presentation epidemiology, etiology, neurobiology, and treatment of bipolar disorder.

Bipolar illness is a serious heritable mood disorder characterized by recurrent episodes of depression and mania and the period of risk extends from prepuberty to senescence.

This chapter provides an overview of the most current research, causes, signs, symptoms, and diagnostic criteria of bipolar I and bipolar II disorder and cyclothymia.

In this region of interest (ROI) based study, both the patients and their healthy co-twins showed a significant decrease in left hemispherewhite matter compared to the healthy control twins, suggesting that left hemisphere white matter in bipolar disorder may reflect genetic factors predisposing to the disorder.

There are no well-designed intervention studies in bipolar patients with anxiety symptoms and the effective treatment of anxiety reduces suicide and the severity of bipolar disorder or improves the response to treatment remains unknown.

Angst (2007) provides more balanced views Angst (2007) provides more balanced views on the much publicised concerns about the on the much publicised concerns about the underdiagnosis of bipolar disorder. Psychi-underdiagnosis of bipolar disorder. Psychiatric diagnoses are not robust entities atric diagnoses are not robust entities (Baca-Garcia (Baca-Garcia et al et al, 2007) and most recent , 2007) and most recent research in mood disorders has arisen from research in mood disorders has arisen from redefining and often rigidly applying the redefining and often rigidly applying the DSM criteria...

Evidence from a family study suggests that panic attacks and panic disorder may be related genetically to bipolar disorder, and Inherited risk for panic disorder with bipolar disorder may indicate a shared genetic etiology for both disorders in some families.

Differential diagnosis of patients whose course of illness includes substantial psychotic and mood syndromes is among the most challenging in psychiatry. The relative temporal preponderance of one or the other of these syndromes over course of illness forms the basis for distinctions among DSM-III-R diagnoses of schizoaffective disorder (SA), bipolar disorder (BPD), and schizophrenia (SZ); and such temporal assessments may be especially difficult to make reliably. Elsewhere we report relatively low reliability of SA and a tendency for it be “confused” with SZ and BPD. In this paper, we identif...

Psychological abnormalities in index offspring were associated with having met diagnostic criteria for psychiatric illnesses and the presence of mood symptoms, rather than preceding them.

Kraepelin distinguished between manic-depressive insanity and dementia praecox on the grounds that patients with the first disorder had better outcomes.

The comparable rates in the two bipolar sub-types support the positioning of bipolar II disorder as a valid condition with strong genetic underpinnings and support the view that bipolar disorder is heritable.

Preliminary data concerning 7 drug-naive DSMIV- TR bipolar I patients who underwent an oral glucose tolerance test suggest that bipolar disorder may be highly associated with abnormal glucose metabolism irrespective of pharmacotherapy.

The early utilization of the rating scale on mixed states, "GT-MSRS", which can demonstrate the level of "mixity" of the mood disorder, can prevent the overlapping between depression-restlessness-irritability-grief-tension-anxiety

A review of the limited literature suggests that this is a relatively severe, refractory subtype of bipolar disorder that only occasionally merits being considered a comorbid disorder.

A large sample of Bipolar disorder and Schizoaffective disorder, Bipolar Type patients and predicted those with a history of psychosis would be more likely to be nicotine dependent, finding patients experiencing more severity of psychosis have more risk of nicotine dependence.

An integrative approach, with several biological measurements using diff erent scales, could yield patterns of biomarkers (biosignatures) to help identify biological targets for personalised and new treatments for all aff ective disorders.

This article reviews DSM-5 changes to symptom criteria for bipolar disorder with a focus on treatment of bipolar depression and cyclothymic disorder.

Clinicians should question depressed patients about symptoms of mania to avoid misdiagnosis, and patients with misdiagnosed bipolar disorder report significantly lower quality of life as measured by the SF-8 and PGWB.

Als kinderen van ouders met een manisch-depressieve stoornis een depressie krijgen, hebben zij een verhoogd risico zelf ook een manisch-depressieve stoornis te ontwikkelen. Ook stressvolle levensgebeurtenissen verhogen de kans op het ontstaan van een eerste stemmingsepisode. Dat blijkt uit onderzoek van Manon Hillegers van het Universitair Medisch Centrum Groningen. Ze promoveert 9 mei 2007 aan de Rijksuniversiteit Groningen. Nu eens zijn ze zwaar depressief, dan weer zijn ze enorm energiek, hebben ze briljante ideeen en kunnen ze de hele wereld aan. Tussendoor hebben patienten met een manisch...

Findings, limited by the small number of BPII-BPII sibling pairs, strengthen the evidence of genetic linkage between BPAD and chromosome 18q, and provide preliminary support for BPII as a genetically valid subtype of BPAD.

It is proposed that the syndrome of mania rather than mood swings is the central distinguishing feature of bipolar disorder, which may be more appropriately viewed as manic disorder.

Findings suggest that the suspected symptoms, in particular chronic, non-episodic irritability, do not constitute a developmental presentation of childhood bipolar disorder, and additional research based on prospective, longitudinal studies is needed to further clarify the developmental trajectories of bipolar disorder and the diagnostic status of chronic,non-epic irritability.

This editorial focuses on discordant twins as a valuable epidemiological design for psychiatric aetiological research, and draws attention to the use of this method in bipolar disorder, revising previous discordant-twin studies.

It is revealed that although inhibition of IMPase dampens SCN molecular rhythms, the period of oscillations remains unchanged and therefore lithium acts upon distinct cellular pathways within the SCN to exert effects on period.

There is a substantial need for the early recognition and treatment of the psychiatric and medical comorbidities of bipolar disorder in primary care, and serious adverse health outcomes may be averted, including substantial morbidity and mortality.

At present, the classification of mental disorders is tightly rooted in categories despite the fact that a dimensional approach may present some clear advantages. In this review, we compare two dimensional approaches that have been put forward in bipolar disorder. On one hand, the “soft” bipolar spectrum focused on the presentation of affective symptomatology and on the other, the staging model based on the progression of the disorders and impairment in functioning in more severe cases. At a first glance, these concepts may sound as difficult to integrate. However, we hypothesize that a common...