Top Research Papers on Schizophrenia

A large, new body of evidence on genetics of schizophrenia is expected through next generation sequencing techniques, which could help to improve diagnostics and early detection and to adapt drug treatment on the genetic profile of patients.

Zusammenfassung Die Auswahl des “richtigen” Antipsychotikums für einen schizophrenen Patienten ist eine komplexe Aufgabe. In dem Artikel werden die wichtigsten Auswahlkriterien in Bezug auf das hauptsächlich zu beeinflussende Zielsyndrom (Akut-/Langzeitbehandlung, Positiv-/Negativsymptomatik, depressive Symptomatik, kognitive Störungen) sowie im Hinblick auf Verträglichkeits- und Sicherheitsaspekte dargestellt. Summary The selection of the best antipsychotic for a schizophrenic patient is a demanding task. In this paper the most important selection criteria are discussed regarding the target s...

Zusammenfassung Die Schizophrenie stellt eine schwere psychische Erkrankung dar, welche für mehr als 50% der Betroffenen einen ungünstigen Verlauf aufweist. Bei Betrachtung der Pathophysiologie hat sich in letzter Zeit in wachsendem Maße gezeigt, dass es sich nicht um eine klassische neurodegenerative Erkrankung, sondern um eine Störung mit einem dysfunktionalen regenerativen Prozess im menschlichen Gehirn handelt. Wie bei allen komplexen Erkrankungen zeigt sich auch in der Ätiologie der Schizophrenie eine Interaktion von genetischen und Umweltfaktoren. Wir wissen inzwischen, dass neben den „C...

Cilj: Uvid u likovnu sklonost odn. zainteresiranost u likovnu umjetnost (kroz razlicite slikarske i kiparske tehnike i materijale: od tempere, akrilika, kasiranog papira do gline odn. izrade uporabnih predmeta ili umjetnickih djela) kao i stupanj socijabilnosti kod skupine bolnicki lijecenih shizofrenih/shizofrenoformnih pacijenata, dragovoljno ukljucenih u kreativnu terapiju- tzv. «Art klub». Uzorak: N=13 (m-6, ž-7).Sociodemografske karakteristike: dob:35+/-5 ; br.st:udat/ož..-1, razv.-1, neož.-11 ; obrazovanje:SSS-10, VSS-3 ; zaposlenost : zap.-3, stud.-2, umir.-2, soc.skrb-6 ; stambeni stat...

A neuro-quantological approach has great potential for understanding the symptoms of schizophrenia as essentially disorders of consciousness as well as the underlying biology of schizophrenia remains metaphorically an undiscovered black box.

MOTS CLÉS Schizophrénie ; Symptômes de premier rang ; Reconnaissance de soi ; Sens de l’agentivité ; Sens du corps Résumé Les symptômes de premier rang de la schizophrénie ont été interprétés comme la conséquence hypothétique d’une altération de la reconnaissance de soi en lien avec une perturbation du sens de l’agentivité (conscience de causer et contrôler l’action). Cependant, le sens du corps (conscience de son propre corps en tant qu’entité organisée, continue et stable), qui participe à la perception que nous avons de nous-mêmes, à l’instar de l’agentivité, n’a jamais été testé à ce jour ...

The view that schizophrenics have been exposed to a parental style of low care and overprotection was assessed in a case-control study of 72 schizophrenics using the Parental Bonding Instrument (PBI) which measures perceived parental characteristics.

The study suggests that long-term stay in hospital causes people with schizophenia partially reducing cognitive activities and regression and shows that patients may improve their life quality, reduce the damage of cognitive function through increasing social contact and taking regular clinical treatment.

Understanding artificial intelligence may help to understand the human brain function and in evolving treatment strategies and it can be identified as artificial Schizophrenia similar to human Sch schizophrenia.

The present work is a systematic study of institutionalism in groups of female schizo phrenic patients in the same three hospitals, and changes occurred in the social attributes of the patients' life in all three hospitals.

The modest, but acceptable inter-centre reliability suggests that for this study the answer to questions c. and d. is a cautious Yes, which will facilitate both the development of epidemiology in the countries concerned and the planning of psychiatric facilities.

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Impairment was non-progressive and largely confined to the period between the onset of the illness and first admission, with catatonics showing the most differential impairment of intellectual ability.

This personally biased review of work on the autonomic physiology of schizophrenia takes as its starting points three interlocking sets of findings and will attempt to extend its coverage from them.

The long-term outcome of chronic schizophrenia has classically been accepted to be pessimistic, most often leading to a terminal demented state, but an examination of recent literature that has followed schizophrenic patients into the involutional years is not so convincing.

Recent findings regarding genetic evidence forHDAC dysfunction in patients with schizophrenia, protein acetylation status, the potential for HDAC inhibitors to be used in conjunction with previously approved antipsychotics, and the potential of HDAC inhibitor to be utilized as standalone treatments for the negative and cognitive symptoms associated with schizophrenia are highlighted.

The term 'dementia praecox' was first used in the Nineteenth Century to express the melancholy of adolescence, accompanied by an atrophy of activity and of intellectual acuteness.

This chapter focuses on mechanisms, such as DNA methylation, hydroxy -methylation, histone modifications or non-coding RNA, as key mechanisms through which environmental factors interact with individual’s genetic constitution which affect the risk of psychotic conditions throughout life.

A test of the Kraepelinian dichotomy would be better served by the use of patients with affective disorders rather than bipolar I disorder (with psychotic symptoms) as the comparator group, and the non-significant differences in grey matter between patients with bipolar I Disorder and healthy volunteers could be a result of sampling bias.

This book is a kind of snapshot of the frontline of schizophrenia research, with 23 chapters addressing neuroimaging, genetics, epidemiology, psychopharmacology, early detection, and psychological treatments, and I found this book to be useful, mainly because many of the contributors very succinctly summarise recent developments in their fields.

The reviewer was particularly intrigued by the Presidential Address by Fritz A. Freyhan, who concludes his address thus: 'The future of psycho pathology appears more promising than at any time in the past.

A test of the Kraepelinian dichotomy would be better served by the use of patients with affective disorders rather than bipolar I disorder (with psychotic symptoms) as the comparator group, and the non-significant differences in grey matter between patients with bipolar I Disorder and healthy volunteers could be a result of sampling bias.

Bruno Schulz re-examined the 722 probands originally studied by Rüdin for mendelian ratios in siblings and found no evidence for a difference in risk of illness in siblings as a function of either the gender or outcome of the proband.

The results showed that having a family history of schizophrenic spectrum disorders correlated with earlier age of schizophrenia debut and higher scores on the Calgary Depression Scale, and may serve as an effective tool for developing more accurate diagnostic strategies in individuals at high risk of developing schizophrenia due to hereditary aggravation.

The author, who worked for many years with Manfred Bleuler, summarises the essence of Bleuler's theory of schizophrenia: that healthy and disturbed psychic processes occur simultaneously.

This work will present some viewpoints concerning both the biological and the psychosocial factors contributing to the vulnerability to schizophrenia, and indicate that these factors are heterogeneous and differently weighted in different cases.

The first-degree relatives of DSM-III schizophrenic probands were diagnosed from chart data by a rater who was blind to proband diagnosis, adding to the growing evidence that the genetic component in schizophrenia may be less than was formerly suspected.

It was considered that although akin to depersonalization, "alienation from objective experience" was the pathology characteristic of schizophrenia.

How the schizophrenia concept deteriorated and became a roadblock to the acquisition of knowledge is noted and implications of a clinical syndrome status and Liddle’s proposal in this context are commented on.

The present author proposes a logopathies/thymopathies dichotomy, which would include all forms of schizophrenia, paraphrenias and paranoias, and would correspond to the affective disorders and also to a great part of the so called “anxiety disorders”.

Preliminary deadline for papers for the 2016 EU tender for medicines and medical equipment for use in the treatment of infectious disease and herbal medicines for animals is set.

denying that the work is one of the numerous studies of mental illness and the family, thereby denying the specific implications of the title. Behind the double-talk is double-think. They say there is no such fact as schizophrenia : †̃¿ . . . we regard it as a palpable error . . . to take it to be a fact. Nor do we assume its existence. Nor do we adopt it as a hypo thesis. We propose no model ofit. . . . Our question is: are the experience and behaviour that psychiatrists take as symptoms and signs of schizophrenia more socially intelligible than has come to be supposed?' To formulate this q...

The author takes the view that the manage ment of ambivalent object-relations is the core problem in schizophrenia, and that group discussions are the key to successful resolution of complications from transference to repulsive behaviour.

New technologies, such as neuroimaging and molecular genetics, are removing the obstacles that once blocked major progress in the field and markedly altered the conception of the nature of schizophrenia.

Vahia IV, Palmer BW, Depp C, Fellows I, Golshan S, Kraemer HC, Jeste DV. Is late‐onset schizophrenia a subtype of schizophrenia?

There is a clear need to rethink the management of schizophrenia and redesign the care pathways to ensure optimal treatment and care for all people living with schizophrenia in Europe.

The political machinery has been set into motion to fight this illness and what has now been labeled an epidemic of huge proportions and those psychiatrists who get specific training in substance abuse and take on the task of providing of medication-assisted therapies for substance abuse are in great demand.

The inhibitory effects of some typical/atypical antipsychotics on the release of inflammatory cytokines and free radicals from activated microglia, both of which have recently been known to cause a decrease in neurogenesis as well as white matter abnormalities in the brains of patients with schizophrenia, may be shown.

The Protocol for Assessing Services for People with Severe Mental Illness and Recommendations for Users and carers and Social Services Recommendations.

This paper analyzed the causes of schizophrenia of Raskolnikov in "Crime and Punishment",from two aspects of the crime motive and understanding of crime;It probes into the deep cause of schizophrenia hidden in his mind that he has thirsty of his spirit unification and regression and the efforts made by himself.He found the home of his soul in the religion later.

Outcome of catatonic schizophrenic patients showed unstable clinical picture, positive family history of psychosis, they had shorter pre- hospitalization interval and better compliance compared to paranoid schyzophrenic patients, not supporting the thesis thatCatatonic schizophrenia has a favorable outcome and better prognosis than other subtypes of schizophrenia.

Theoretical conceptualizations of schizophrenia have undergone significant change in the past century, and models that encompass complex gene—environment interactions and neural pathways that mediate the relation between psychosocial events and brain dysfunction are introduced.

Progress in psychiatric epidemiology has been slower than in other areas-for example, cardiovascular disease or cancer epidemiology, because of certain methodological problems that are just now being overcome.

It is postulated that the peanut factor may act by enhancing thrombocyte action without affecting fibrin production, or by some effect on capillary integrity, and the authors postulate that claims for the effectiveness of other supplements, such as vitamin Bu, <Estrogens, etc., have been advanced but have not been substantiated.

Signs and symptoms of schizophrenia include false perceptions called hallucinations, and strongly held false beliefs (delusions) are also characteristic of schizophrenia.

It is concluded that convulsive or insulin treatment is justifiable in pregnant women because of the apparent harmlessness of convulsive seizures due to these drugs and to epilepsy.

The overall prognosis is poor; many patients live restricted lives and there is a high rate of suicide, however, some patients return to normal functioning and the management is complex, antipsychotic drugs are effective in reducing symptoms.

There is clearly a need for a deeper understanding of the molecular mechanisms underlying this debilitating illness.

The observed patterns of connectivity indicate that core regions of the frontal-parietal net- work involved in both working memory and selective attention play a crucial role in the filtering of information by modulating the processing of information in visual areas.

The evidence-based diagnosis and treatment of persons with schizophrenia should be carried out in a multiprofessional process, with close involvement of the affected persons and the people closest to them.