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Molecular Biology

88 Citations2010
D. Margulies
Current Protocols in Immunology

It is worth noting that a number of advances in molecular biology—such as the development of early cloning methods and the refinement of cloning techniques that take advantage of antibody enrichment—improved rapidly once immunological expertise was drawn into the methodology.

Abstract

Immunology, like virtually every other branch of modern biology, has benefited from the technological and scientific advances in molecular biology. From the cloning of a myriad of immunologically relevant genes—including those that encode antibodies, T cell receptors, major histocompatibility complex antigens, lymphokines and their receptors, and various lymphocyte accessory molecules—to the generation of transgenic mice or mice that lack a selection of these genes, the methods of molecular biology have already left a permanent imprint on our understanding of the immune system. Conversely, it is worth noting that a number of advances in molecular biology—such as the development of early cloning methods and the refinement of cloning techniques that take advantage of antibody enrichment—improved rapidly once immunological expertise was drawn into the methodology.