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GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer’s disease
28 Citations•2021•
Peng Xu, Jerry C Chang, Xiaopu Zhou
The Journal of Experimental Medicine
This study demonstrates that GSAP regulates lipid homeostasis in mitochondria-associated membranes (MAM), which affects mitochondrial function associated with the disease.
Abstract
GSAP plays an important role in Alzheimer's disease, but the underlying cellular and molecular pathways remain unclear. Using unbiased multi-omics approaches, this study demonstrates that GSAP regulates lipid homeostasis in mitochondria-associated membranes (MAM), which affects mitochondrial function associated with the disease.