GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer’s disease

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Abstract

GSAP plays an important role in Alzheimer's disease, but the underlying cellular and molecular pathways remain unclear. Using unbiased multi-omics approaches, this study demonstrates that GSAP regulates lipid homeostasis in mitochondria-associated membranes (MAM), which affects mitochondrial function associated with the disease.