The expression and significance of survivin,Bcl-2 and p53 in ovarian epithelial tumors
Survivin,bcl-2 and mutant p53 are involved in neoplasia of ovarian epithelial tumors,survivin and p 53 are correlated with malignant tumor, and a correlation between survivin and mutantp53 is also confirmed.
Abstract
Objective:To explore the expression and clinical significance of apoptosis related genes-survivin,bcl-2 and p53 protein in ovarian epithelial tumors.Methods:The expression levels of survivin,bcl-2 and p53 protein in 12 cases of normal ovarian tissues,22 cases of benign ovarian epithelial tumors,19 cases of borderline tumors,34 cases of malignant ovarian epithelial tumors and 12 cases of normal ovarian tissues were detected by immunohistochemical staining from 2002 to 2007.Results:The expression levels of survivin,bcl-2 and p53 protein in benign ovarian epithelial tumors were lower than those in malignant ovarian epithelial tumors,but there was no significant difference in the expression level of bcl-2 between three groups. There was no correlation between the expression levels of survivin,bcl-2 and p53 protein and clinical staging,the expression of survivin was related to p53.Conclusion:Survivin,bcl-2 and mutant p53 are involved in neoplasia of ovarian epithelial tumors,survivin and p53 are correlated with malignant tumor,and a correlation between survivin and mutant p53 is also confirmed.Multiple gene interactions might govern the pathogenesis of ovarian cancer.