Expanded CD8+ T cells of murine and human CLL are driven into a senescent KLRG1+ effector memory phenotype

It is observed that increments of CD8+ effector memory T cells in human CLL and also mouse CLL were due to an expansion of the inhibitory killer cell lectin-like receptor G1 (KLRG1) expressing cellular subset, and higher plasma levels of the natural K LRG1 ligand E-cadherin were detected in CLL patients compared to normal donor controls.