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A total of four bacteria isolated from commercial food products viz., Amul Probiotic Ice-cream, Nestle Baby & Me and Yakult were compared against two potential indigenous probiotic isolates from traditional fermented foods of NorthWestern Himalayas along with reference strain Lactobacillus rhamnosus GG-ATCC 53103 for antigenotoxic potential. Indigenous isolate ADF10, Lactobacillus plantarum showed highest antigenotoxicity (>90% against 4-NQO and furazolidone) among all the isolates used in this study followed by commercial isolate L4, Bifidobacterium lactis from Nestle Baby & Me. This study showed that AdF10 can be used for specific enrichment of fermented foods to enhance their health potential benefits.