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After a brief description of the goal of Fermi National Accelerator Laboratory (Fermilab) this paper poses and answers three questions related to Quality Assurance (QA) at the Laboratory. First, what is the difference between 'orthodox' and 'unorthodox' QA and is there a place for 'orthodox' QA at a laboratory like Fermilab. Second, are the deeper philosophical and cultural frameworks of high-energy physics acommodating or antagonistic to an 'orthodox' QA Program. Finally, faced with the task of developing an institutional QA program for Fermilab where does one begin. The paper is based on experience with the on-going development and implementation of an institutional QA Program at Fermilab. 10 refs.