Top Research Papers on Depression

Preface vii PART ONE: OVERVIEW 3 1. The Macroeconomics of the Great Depression: A Comparative Approach 5 PART TWO: MONEY AND FINANCIAL MARKETS 39 2. Nonmonetary Effects of the Financial Crisis in the Propagation of the Great Depression 41 3. The Gold Standard, Deflation, and Financial Crisis in the Great Depression: An International Comparison - With Harold James 70 4. Deflation and Monetary Contraction in the Great Depressim An Analysis by Simple Ratios - With Ilian Mihov 108 PART THREE: LABOR MARKETS 161 5. The Cyclical Behavior of Industrial Labor Markets: A Comparison of the Prewar and Pos...

Up-to-date guidance for the diagnosis and treatment of major depressive disorder, including practical considerations for delivering optimal and efficient care for these patients is offered.

The purpose of this review was to identify and analyze risk factors for the development of depressive disorders in women in the postpartum period, to study some manifestations of postpartum depression.

The participant will be able to understand the physiologic and psychologic mechanisms through which exercise may reduce symptoms of depression.

The importance of addressing maternal and paternal mental health issues using a family-focused approach to reduce the adverse effects on offspring mental health rather than the conventional gender- focused approach limited to maternal prenatal and postnatalmental health issues or individual treatment of the offspring is suggested.

Preventive administration of dexmedetomidine in the early postpartum period significantly reduced the incidence of PPD and postoperative pain, while also improving sleep quality.

Zuranolone demonstrated significant improvements in depressive symptoms and was generally well tolerated, supporting the potential of zuranol one as a novel, rapid-acting oral treatment for PPD.

Depression in people aged over 65 is under- recognised and under-treated although, when treatment for older patients is given, it is as effective as for younger adults. More people aged over 65 commit suicide than any other age group and suicide attempts in older people are more likely to be successful.

A synopsis of some of the putative neurobiological mechanisms underlying ketamine’s rapid-acting antidepressant effects is provided before outlining future research directions, including the need to identify biomarkers for predicting response and treatment targets that may be used in the development of next-generation rapid- acting antidepressants that may lack ketamine's side-effects or abuse potential.

For acute-phase treatment response, antidepressants may reduce depressive symptoms when compared with placebo, even though the evidence is very uncertain, and when measured as a proportion of people who had depression at the end of the study, there was no difference.

A large body of evidence suggests that anhedonia is, at least partially, independent from depression, therefore it needs careful assessment and targeted treatment.

The findings of this randomized clinical trial suggest the need for more effective therapeutic interventions and biomarkers in this heterogeneous clinical condition.

Major depressive disorder is a condition marked by low or irritable moods, along with physical symptoms such as problems with sleep, energy, and appetite. Treatment options include counseling/psychotherapy (e.g. interpersonal/attachment-based psychotherapy to address interpersonal stresses), lifestyle interventions (e.g. sleep hygiene, proper nutrition, regular exercise), as well as medication options (such as SSRIs).

The results indicated that patients with DWB might perform differently from those with UD but similarly to those with BD with cognition impairment.

Whether acylcarnitines might be the biomarkers for the diagnosis of depression and provide new ideas to treat depression is explored.

Exposure to family MD during childhood and adolescence was associated with increased risk of MD but did not vary by gender or type of kinship, and the associated risk increased with number of affected family members.

Children with MDD consume fewer healthy foods than non-MDD children, with little variation by dietary measure, according to the Youth Healthy Eating Index.

This case–control study investigated genetic differences between PND and MDD outside the perinatal period (non‐perinatal depression or NPD).

This review focused on studies investigating post-mortem brain tissue of individuals with depression, as well as research aiming to elucidate the biomarker potential of miRNAs in depression and antidepressant response.

Results showed that levels of anxiety and depressive symptoms increased from 24 weeks gestation to postpartum, whereas stress levels decreased during pregnancy but increased in post partum.

Besides targeting those with existing clinical depression, research and policies should also focus on educational and supportive mitigation efforts to curb depressive symptoms among adolescents before escalation.

TRD is associated with disproportionate health care costs and unemployment, suggesting potentially large economic and societal gains with effective management.

It is suggested that depression associated with HC use can indicate postpartum depression susceptibility and may provide evidence for a link between depressive episodes with possible hormonal contributions and point to the existence of a subgroup of women sensitive to hormonal transitions across their reproductive life spans.

This article summarizes an investigation of the stigmatization of depression in Thailand to determine whether there is a relationship between depression literacy and personal stigma and perceived stigma. This mixed-method study utilized two questionnaires, the Depression Literacy Questionnaire and the Depression Stigma Scale, by Griffiths et al. and subsequently asked participants for their opinions of depression and stigmatization within the Thai context. About 914 online surveys were processed using correlational and descriptive analysis. Results indicate that the depression literacy score w...

The microRNAs play a regulatory role in the pathophysiology of depression, involving dysregulation of monoamines, abnormalities in neuroplasticity and neurogenesis, hyperactivity of the HPA axis, and Dysregulation of inflammatory responses.

This study provides a way to aggregate data across various depression measures and timepoints, such that researchers and clinicians now have the ability to directly compare and combine EPDS data with PROMIS and other depression measures already score-linked toPROMIS.

Effective first-line depression treatments include specific forms of psychotherapy and more than 20 antidepressant medications, which have approximately equal likelihood of success based on a network meta-analysis.

Niedergeschlagenheit, emotionale Leere, Antriebslosigkeit, Interessenverlust und zahlreiche körperliche Beschwerden sind wesentliche Merkmale von akuten Depressionen. Sie gehören zu den häufigsten psychischen Beeinträchtigungen und können in allen Lebensphasen auftreten. Akute Depressionen zählen mit zu den häufigsten Gründen für Krankschreibung, Arbeitsunfähigkeit und Frühberentung und haben damit gesamtgesellschaftliche Auswirkungen. Inzwischen liegen erfolgreiche psychotherapeutische Behandlungsmöglichkeiten vor, die u.a. Eingang in die Nationale Versorgungsleitlinie unipolare Depression ge...

The results suggest that major depressive symptoms observed among individuals with prior COVID-19 illness may not reflect typical depressive episodes, and merit more focused neurobiological investigation.

This phase 2, double-blind, randomized, controlled trial involving patients with long-standing, moderate-to-severe major depressive disorder did not show a significant difference in antidepressant effects between psilocybin and escitalopram in a selected group of patients.

Replacing treatment-resistant depression with quasi-tenacious depression (QTD), a model and terminology that are derived from a potentially measurable outcome, the tenacity index (TI), which predicts that in theory remission is achievable by providing suitable treatments at hand.

In this narrative review, the evidence for the serotonin hypothesis of depression is summarized, focusing on psychopharmacology and molecular imaging, as well as systems-level neuroscience.

Time-varying vector autoregressive models are conducted to investigate the idiographic symptom networks of the entire sample of participants collected to date, suggesting that the composition and driving factors of MDD are not only heterogeneous across persons but also within-persons across time.

Screening patients with the EPDS during perinatal and postpartum care could facilitate establishing a line of care to improve the wellbeing of mother and infant and there is a significant association between the occurrence ofperinatal depression and the aforementioned psychosocial factors.

Tweet: Antidepressants may decrease the incidence and severity of poststroke depression, enhance recovery, and increase years of survival.

This systematic review and meta-analysis examines data from published prospective studies of adults to gauge the dose-response association between physical activity and incident depression.

Introduction: Self-verification theory makes the controversial claim that people higher in depression seek to confirm their depressed identity. Recent evidence suggests that people with higher self-reported depression severity alter their reports of self-relevant information to seem depressed. This article discusses the results of two preregistered studies that examined whether people with higher self-reported depression severity will distort memories of previously encoded events to seem depressed. Methods: In Studies 1 and 2, participants (total N = 665) self-reported their depression severit...

The current understanding about the role of inflammation in depression, the mechanisms that are involved, and how it is possible to innovate and develop new therapeutics of depression in the context of neuroinfieldsammation are detailed.

Even low intensity activities such as walking or yoga are beneficial

This cohort study evaluates the association between perinatal depression and risk of short- and long-term suicidal behavior.

Tiago Costa from Delft University of Technology explores the potential of neuroimaging techniques, specifically non-invasive electroencephalography (EEG), in detecting biomarkers for depression. Major Depressive Disorder (MDD) is a prevalent and complex mental disorder posing significant challenges to both individuals and societies worldwide. An early and accurate diagnosis of depression is essential for effective treatment and management. In recent years, advancements in neuroimaging techniques have opened new avenues for identifying biomarkers that could aid in the diagnosis and understa...

An overview of the latest findings in the rapidly evolving field of computational language analysis for the detection of depression, with special focus on the current methodological advances with regard to feature extraction and computational modeling techniques.

Evidence supporting the efficacy of brexanolone for the treatment of PPD is discussed, which opens a promising new horizon for neurosteroid-based therapeutics for mood disorders.

When screening for major depression, a HADS-D cut-off value of seven or higher maximised combined sensitivity and specificity, similar across reference standards and subgroups and when published results from studies that did not contribute data were included.

Breastfeeding can promote hormonal processes that protect mothers against postpartum depression by attenuating cortisol response to stress and the mother whom giving birth then directly breastfeeding their child, will reduce the mothers stress.

The main literature in the last decade was mainly searched and summarized on PubMed, Google Scholar, Scopus, Web of Science, and other electronic databases with the keywords “depression, sugar, fat, protein, lithium, zinc, magnesium, copper, iron, and selenium”.

In this randomized clinical trial of 150 participants with treatment-resistant unipolar depression, 12 weeks of 20 mg/d of simvastatin added to standard care did not show a statistically significant benefit compared with placebo added tostandard care on the overall course of depressive symptoms.

This work reviews the diagnosis and management of depression in adolescents, drawing on available evidence and recommendations from international guidelines, as outlined in Box 1.

It is found that older adults with LLD have shorter telomere than healthy controls, especially those with a more severe depressive episode, which indicates that these individuals may be at higher risk of age-associated adverse outcomes linked to depression.

The main barriers to implementing PROMs in gender-affirming care were issues with evidence strength and quality of the PROM, engaging participants, and complexity of the PROM.