Top Research Papers on PCOS

Women with PCOS have two types of hormones, insulin and androgens, that can be made in higher levels than in women without PCOS, which is more common in women of Asian, Aboriginal and Torres Strait Islander and African backgrounds.

The symptoms of polycystic ovary syndrome include menstrual cycle disturbance and features of hyperandrogenism (hirsutism, acne and alopecia), with associated fertility problems, obesity and psychological issues.

In view of new knowledge of the pathomechanism of PCOS, highly effective interventional options with insulin sensitizers, and in particular the oral antidiabetic, metformin, are now available in addition to the classical stimulation regimes for the treatment of infertility.

Several physical symptoms appear in woman suffering from PCOS like irregular periods, hirutism etc, and to reduce the symptoms and the problem of infertility associated with it, researchers have come up with certain treatments.

Polycystic ovary syndrome (PCOS) is a health condition in women that can occur any time after puberty and involves a reproductive hormone imbalance which affects the ovaries, causing issues such as irregular menstrual cycles, ovarian cysts, and infertility. The precise cause of PCOS is still unknown, but it is believed that genetics, high levels of sex hormones, and high insulin levels may be risk factors. Many other conditions are commonly seen together with PCOS, such as diabetes, depression, and anxiety, as well as endometrial cancer, but researchers are still investigating whether these is...

Obesity is associated with PCOS and weight loss is beneficial in improving symptoms, but what is the main cause of insulin resistance?

Although the cause of PCOS is not known, it appears that PCOS may be related to many different factors working together, including insulin resistance, increased levels of hormones called androgens, and an irregular menstrual cycle.

Polycystic ovaries syndrome is one of the most common female hormonal disorders and cares aim to attenuate the marks of the hyper-androgenism (hormonal treatment and cosmetic) and to correct cardiovascular, respiratory and gynaecological risk factors.

A classification ofPCOS according to the presence of hyperandrogenemia and/or hirsutism will be shown to reconstruct the concept or definition of PCOS and usefulness of this classification will be revealed by showing endocrinological and morphological aspect of each class.

There are links between PCOS and endometrial carcinoma, obesity, cardiovascular disease and diabetes, so symptoms related to PCOS are now evaluated and treated both for short-term relief and for long term sequels.

Women with this disorder often have a mother or sister who has symptoms similar to those of PCOS, which is thought to be one of the leading causes of female infertility.

Polycystic ovary syndrome or disease is a multisystem endocrinological disorder that may present with hyperandrogenism, ovarian dysfunction, obesity, menstrual abnormalities, and multiple ovarian cysts.

There is a growing recognition of the importance of PCOS as a significant health issue affecting millions of women worldwide, and continued research efforts will be critical for improving diagnosis, treatment, and long-term outcomes for those affected by the condition.

Treatment is broadly aimed at tackling (IR), effects of hyperandrogenism, irregular menstruation, and infertility, and efficient management of PCOS provides a prospective window of opportunity to avoid the risk of associated complications.

The polycystic ovary syndrome is defined as a combination of hyperandrogenism (hirsutism and acne) and anovulation (oligomenorrhea, infertility, and dysfunctional uterine bleeding), with or without the presence of poly Cystic ovaries on ultrasound.

This book has provided useful information for readers to timely diagnosis, prevention of progress and treatment of the disease, which is hoped to be useful.

It is suggested that because of hypoandrogenism usually developing after age 35, HH-PCOS at that age becomes relatively treatment resistant to in vitro fertilization (IVF) and evidence that androgen supplementation overcomes this resistance is offered.

Recent research reveals that PCOS is a lifelong syndrome that first manifests during pregnancy, despite the fact that it was traditionally thought to be a disorder that only affected adult women.

Polycystic ovary syndrome is a very common condition that happens in 5 to 10% of young women, and it tends to run in families, but it isn't caused by a single gene.

A larger sample size and a controlled prospective study would be able to shed light on the disease’s prevalence as well as other environmental factors that contribute to PCOS manifestation in the Indian population.

A systematic review aimed to answer the following clinical question: What are the effects of metformin on hirsutism and menstrual frequency in women with PCOS and the effectiveness and safety of the following interventions: metformin compared with placebo/no treatment, metformin compared with weight loss intervention, or metformin compared with cyproterone acetate-ethinylestradiol.

This review focuses on characteristic markers of OS in PCOS and the relationship between OS and PCOS related to insulin resistance (IR), hyperandrogenemia, obesity, chronic inflammation, cardiovascular diseases (CVD) and necrosis.

Polycystic ovary syndrome (PCOS) is an endocrine systemic disorder with a prevalence of between 5% and 20% that commonly affects childbearing-aged women and is known to cause menopause in around 20% of women.

Polycystic Ovary Syndrome (PCOS) juga dikenal sebagai hyperandrogenic anovulation (HA), merupakan kelainan sistem endokrin yang menyebabkan gangguan kesuburan wanita usia reproduktif. PCOS melibatkan ketidakseimbangan kadar luteinizing hormone (LH) dan follicle-stimulating hormone (FSH), resistensi insulin, dan kelainan metabolisme. Clomiphene citrate masih menjadi pilihan terapi utama untuk menstimulasi ovulasi pada kasus PCOS. Metformin juga menurunkan kadar androgen yang dapat meningkatkan terjadinya ovulasi spontan. Terapi lini kedua adalah gonadotropin dan bedah laparoskopi ovarium.Polycy...

All women with PCOS must be assessed for IR at the outset and then periodically at 1–3 years intervals depending on their individual risk, keeping in mind the higher risk of T2DM among the South Asian population.

Ovarian biology is used to describe a strategy to aid understanding and explanation of PCOS and this framework can be also be used to teach aboutPCOS and to inform different approaches to its management.

CD43 downregulation results from the shedding of microparticles released during apoptosis but unrelated to the blebbing, which result from different signaling pathways and can occur independently from one another.

Julia Clough tells how she was finally diagnosed with PCOS in December 2001, aged 31, after numerous visits to her GP regarding sleeplessness, anxiety and depression which she suffered for up to five days, every month or every other month.

A comprehensive overview of the PCOS epidemiology, aetiology, clinical presentation, diagnostic standards, and therapeutic choices is provided to enhance the understanding of PCOS among healthcare professionals.

Polycystic overy syndrome is not associated with higher levels of prolactin, measured in daily profiles and hyperprolactinemia does not seem to be more frequent in PCOS women than in healthy subjects and it should not be considered as characteristic feature of PCOS.

The present study has demonstrated increase in mean serum homocysteine concentrations in women with PCOS, and this has been recognized recently as a risk factor for cardiovascular diseases.

There is increased prevalence of hypothyroidism in patients with PCOS, more common in the age group of 26-30 years, and Screening for hypothy thyroid profile in PCOS patients will decrease the morbidity, improving quality of life.

NAFLD is frequent in patients with PCOS confirming a relevant clinical association between these two conditions and women withPCOS should be screened for liver disease.

Focus on sexual dysfunctions in PCOS has been emphasized only recently after high rates of its prevalence have been found and proper assessment and management of sexual Dysfunctions should be given its due importance.

Because PCOS may contribute to earlier development of hypertension, as well as pre-hypertension, therefore it is advisable to monitor blood pressure systematically, to control known risk factors, and to initiate the treatment of hypertension when the disease occur.

Different hypotheses of thiazolidinediones actions to improve PCOS are reported in this review (steroid secretion by ovarian cells ; insulin sensitivity in muscle and adipocyte and fat redistribution).

The current state of knowledge concerning particular genes, products of which seem to take part in the modulation of the clinical sings of the syndrome are presented, indicating that PCOS may be a result of several genes abnormalities interactions.

In all PCOS patients, kisspeptin showed positive correlations between LH and leptin levels, and in fact, the serum levels ofkisspeptin and leptin does not differ statistically between PCOS and healthy women.

Women who have PCOS are at high risk for several serious complications, some of them can be life threatening complications, so early diagnosis and treatment helps to reduce the risk for many of the complications.

This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, as to provide real-time information about the pre- and post-surgical complications of pregnancy and childbirth in Kashmir.

The understanding of miRNAs, particularly in relation to PCOS, is currently at a very early stage, and additional studies will yield important insight into the molecular mechanisms behind this complex and heterogenic syndrome.

Weight reduction is difficult to achieve in obese women with PCOS than normal individuals so a comprehensive lifestyle intervention program including individualized diet with moderate energy restriction based on basic healthy eating principles, at least 30 minutes moderate physical activity 3-5 days a week and behavior modification approach is required.

ABSTRACT

The current state of knowledge concerning particular genes, products of which seem to take part in the modulation of the clinical sings of the disease are presented.

The present knowledge on the hormonal background of PCOS is summarized to give some clinical examples how the present knowledge can be applied to treat PCOS patients according to their current problem, such as menstrual cycle disorder, hirsutism, infertility or to prevent late consequences as diabetes mellitus.

The goal of this work was to provide a review of papers pertinent to polycystic ovaries, including causation, symptoms, diagnostic, and treatment aspects, as well as its association with Cardiovascular and arterial hypertension illnesses.

Polycystic ovary syndrome is an endocrinological disorder where there is hyperandrogenism, ovarian dysfunction and multiple ovarian cysts and the most common presenting features are hirsutism, acne, metabolic syndrome and biochemical hyperandrogens.

Non-pharmacologic strategies which improve insulin sensitivity such as weight loss, physical activity and restriction of foods with high glycemic index should be the first line of therapy in women with PCOS.

Current understanding of the pathogenesis of the syndrome suggests that it is a complex multigenic disorder (a genetic problem caused by more abnormalities in the genetic information DNA).

Serum AMH is synthesized by small antral follicles, which are precisely those seen on ultrasound and could help us to diagnose PCOS but there are many aspects that still require elucidation.