Top Research Papers on PCOS

This third edition covers the aetiology, pathology, impact on fertility and effective medical and surgical management of PCOS, and a new chapter on the patient's perspective has been included, bringing valuable insight into the lived experience of the condition.

The needs and priorities of those with PCOS are discussed, including lifestyle, and medical and infertility treatment, and the status of international evidence-based guidelines and translation are discussed to support patient self management, healthcare provision, and to set research priorities.

Despite affecting ~11-13% of women globally, polycystic ovary syndrome (PCOS) is a substantially understudied condition. PCOS, possibly extending to men's health, imposes a considerable health and economic burden worldwide. Diagnosis in adults follows the International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome, requiring two out of three criteria - clinical or biochemical hyperandrogenism, ovulatory dysfunction, and/or specific ovarian morphological characteristics or elevated anti-Müllerian hormone. However, diagnosing adolescents omits ovarian mo...

The rationale for and the limitations of these criteria are reviewed, as well as which criteria to use and when, and the promise of objective data mining approaches for biologically relevant disease classification are discussed.

The immune regulation involved in the pathogenesis of PCOS is summarized to pave the way for the development of better PCOS treatment options in the near future.

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The data suggests that the body mass index was not correlated with increased LH/FSH ratio, which was the same in normal BMI women, and healthcare professionals need to think about ways to normalize this ratio beyond weight reduction.

The complexity of the disorder, and the impact on quality of life, requires a timely diagnosis, screening for complications, and management strategies for the long-term health issues associated with polycystic ovary syndrome.

The associations between MPO activity and the MPO G‐463A and CYBA C242T polymorphisms in Chinese women with PCOS are investigated.

The main objective is to provide a background of autophagy in the ovary, its possible connection with PCOS and suggested a novel proposal for future studies to aid a better understanding of PCOS pathogenesis.

Polycystic ovary syndrome (PCOS) affects 1 in 5 women of reproductive age, and is characterized by menstrual irregularities, clinical or biochemical hyperandrogenism, and the presence of polycystic ovary morphology. One of the recommended treatment strategies in the international evidence-based guidelines is lifestyle modification, which includes diet and exercise, with the aim of improving a range of health outcomes. The incurable nature of PCOS reinforces the importance of developing novel and innovative symptomatic relief strategies, which are currently the only available approaches for imp...

This review intends to emphasise the key role of oxidative stress and chronic inflammation in PCOS pathogenesis; however, the exact molecular mechanism is mostly unknown and requires further investigation.

A narrative review was conducted to provide an update and summarize the available evidence on the management of polycystic ovary syndrome related infertility and suggest alternative and adjunctive treatments, like inositol, vitamin D, bariatric surgery and acupuncture.

The findings suggest that diet is an effective, acceptable and safe intervention for relieving IR, and professional dietary advice should be offered to all PCOS patients.

Attention should be directed to maintain a high standard of care for complex patients such as many women with PCOS and provide relevant practical recommendations for optimal management in the setting of this fast moving pandemic.

The interplay between inflammatory cytokines in the PCOS ovary strongly implies that inflammation is one of the most potent risk factors of PCOS, which should be considered for new treatment or management of the disease and to improve women's health.

How AGE formation, inflammation, and oxidative stress are significantly essential in PCOS progression is summarized, and a collection of specific genes phenotypically linked with PCOS is outlined.

This paper focuses on the data-driven diagnosis of polycystic ovary syndrome (PCOS) in women and finds that RFLR is suitable for reliably classifying PCOS patients.

There is sufficient evidence to support that endometrial function is altered in women with PCOS, whether clinical features of PCOS affect the endometrium, and whether there are evidence-based interventions to improveendometrial dysfunction in PCOS women.

Evidence that altered epigenetic and developmental programming influence the pathogenesis and familial transmission of PCOS is discussed, suggesting a path towards novel treatment strategies for PCOS-like phenotypic traits.

Polycystic ovary syndrome is the most common endocrine disorder among women of reproductive age and is hallmarked by hyperandrogenism, oligo-ovulation, and polycystic ovarian morphology, which is associated with several cardiometabolic abnormalities.

The results suggest that a KD may be considered as a valuable non pharmacological treatment for PCOS and longer treatment periods should be tested to verify the effect of a KD on the dermatological aspects of PCOS.

Polycystic ovary syndrome (PCOS) is the most common reproductive and metabolic disorder affecting women of reproductive age. PCOS has a strong heritable component, but its pathogenesis has been unclear. Here, we performed RNA sequencing and genome-wide DNA methylation profiling of ovarian tissue from control and third-generation PCOS-like mice. We found that DNA hypomethylation regulates key genes associated with PCOS and that several of the differentially methylated genes are also altered in blood samples from women with PCOS compared with healthy controls. Based on this insight, we treated t...

A review deliberates on the variety of risk factors potentially involved in the etiology, prevalence, and modulation of PCOS, in addition to plausible therapeutic interventions, including miRNA therapy and the eubiosis of gut microbiota, that may help treat and manage PCOS.

Which animal models are more suitable for contributing to the understanding of the etiology and pathophysiology of PCOS are detailed and advantages and limitations of hormonal or genetic manipulation of animal models, as well as of naturally occurring PCOS-like females are highlighted.

An extended machine learning classification technique for PCOS prediction has been proposed, trained and tested and the best performing results are obtained by incorporating the “VGGNet16” pre-trained model with CNN architecture as feature extractor and then stacking ensemble model with the meta-learner being “XGBoost” model as image classifier with an accuracy of 99.89% for classification.

An extensive narrative review of the broadly understood modifications to the lifestyles of women with polycystic ovary syndrome (PCOS), combining PCOS entries with causes, diseases, diet supplementation, lifestyle, physical activity, and use of herbs.

Extensive international engagement accompanied by rigorous processes honed both diagnostic criteria and treatment recommendations for PCOS during adolescence and endorsed the benefits of healthy lifestyle interventions to prevent excess weight gain and should be recommended.

It is speculated that reduced reproductive potential in women with PCOS may be caused by altered oocytes, embryo and endometrial competence, and infertility-related co-morbidities as well as an increased risk of pregnancy complications.

The data from the available randomized controlled trials (RCTs) suggested vitamin D supplementation reduced insulin resistance and hyperandrogenism, as well improving the lipid metabolism of patients with PCOS to an extent.

The accumulation of genome-wide association studies in PCOS has enabled multiple MR analyses identifying factors that may cause PCOS or be caused by PCOS, and this knowledge will be critical to future development of measures to prevent PCOS in girls at risk as well as prevent complications in those who have PCOS.

While optimising sleep and emotional wellbeing may aid symptom management in PCOS, research exploring the efficacy of clinical interventions is lacking, and robust clinical trials are warranted to expand the relatively limited evidence-base regarding holistic lifestyle management.

Recommendations for women with PCOS include vigorous aerobic exercise and resistance training to improve measures of insulin sensitivity and androgen levels and to review the evidence for the impact of various exercise interventions on hormone levels.

Understanding more about PCOS would be beneficial to find new medications implying the effect via the novel discovered routes, and it would be helpful to do further research and run well-designed clinical trials on this subject.

Assessment of the effects of Vit E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers, and hormonal functions in PCOS women based on the clinical trial's results showed that vitamin E supplementation made statistically significant improvements in triglyceride (TG) and low-density lipoproteins (LDL) levels.

The pathophysiological roles of chronic low‐grade inflammation mediators including inflammasome‐related cytokines, interleukin‐1 β (IL‐1β), and IL‐18 in PCOS development are discussed.

The present review is aimed at bringing together the most significant information regarding the role of oxidative stress in promoting CVD among PCOS patients, but also at highlighting the need for determining the efficiency of antioxidant therapy in these patients.

The results of this study have indicated that women with PCOS suffer from depression, anxiety, and experience a lower quality of life, whereas their sexual function is not distinct from that of healthy women.

The closely relationship among gut microbiota, fecal metabolites, and serum sex hormones may play a role in the related changes caused by hyperandrogenemia.

A deep understanding of the pattern of the growth in PCOS for HA and IR can help ameliorate the condition, along with adjustments in nutrition and life, as well as the discovery of new medicinal products.