Top Research Papers on Weight Loss

There is no single best strategy for weight management, and strategies for weight loss and its maintenance should be individualized, and healthcare providers must choose the best strategy based on patient preferences.

The evidence supports the recommendations for intakes of protein above the current guidelines of 0.8 g/kg body weight/d for the healthy elderly population to also be incorporated into the dietary prescription for weight management in this age group.

This Viewpoint explores the effects of weight loss achieved through GLP-1–based antiobesity medications on weight regain, fat-free mass, and skeletal muscle mass in people with obesity.

Key common influential characteristics of success were identified, which can inform future prospective studies and weight management initiatives, and the first systematic review of information about successful weight loss maintenance obtained from weight control registries is reviewed.

Insight is sought on unanswered questions over how weight loss is achieved following bariatric surgery which may eventually lead to safer, nonsurgical weight-loss interventions or combinations of medications with surgery.

Obesity is best managed by a multidisciplinary clinical team that integrates diet, exercise, and pharmacotherapy and bariatric surgery is needed to manage T2D and obesity in select patients.

Research into factors potentially contributing to inter-individual variability in response to treatments for obesity, with a focus on studies in humans is reviewed, to guide more personalized approaches to the treatment of obesity.

The reported impact of weight loss by diet, exercise, or bariatric surgery on circulating and tissue-specific glucocorticoid levels is summarized and the therapeutic possibility of reversing glucoc Corticoid-associated metabolic disorders is examined.

A high-intensity, lifestyle-based treatment program for obesity delivered in an underserved primary care population resulted in clinically significant weight loss at 24 months.

Clinicians should recommend an adapted lifestyle, and when necessary, a drug combination tailored to individual needs and comorbidities, as an update on promising diets and pharmacological aids is presented.

Although most adults with overweight or obesity experienced 5% or greater weight loss with treatment, the benefit was greater with tirzepatide.

Data indicate that therapeutic targeting of the GDF15–GFRAL pathway may be useful for maintaining energy expenditure in skeletal muscle during caloric restriction, and this effect of GDF15 to maintain energy expenditure during calorie restriction requires a GFRAL–β-adrenergic-dependent signalling axis that increases fatty acid oxidation and calcium futile cycling in the skeletal muscle of mice.

The Mediterranean diet is a plant-based,high-fat, high-unsaturated fat dietary pattern that has been consistently associated with lower rates on non-communicable diseases and total mortality in prospective studies and with reduced CVD in the PREDIMED trial.

Among patients with obesity, a regimen of time-restricted eating was not more beneficial with regard to reduction in body weight, body fat, or metabolic risk factors than daily calorie restriction.

Patients with COVID‐19 disease are prone to develop significant weight loss and clinical cachexia, and there is a high medical need to prevent long‐term disability due to acute COVID­19 disease.

This review presents the current knowledge about diseases associated with childhood obesity and how they are affected by weight loss, and indicates that early weight loss—that is, before puberty—is more beneficial, but there are marked disease‐specific differences.

A strategy combining exercise and liraglutide therapy improved healthy weight loss maintenance more than either treatment alone and was associated with improvements in the glycated hemoglobin level, insulin sensitivity, and cardiorespiratory fitness.

A generalization for these methods that manifests as a scaling parameter which balances the relative importance of the different constraints imposed by partial differential equations is introduced, which derives a choice for the scaling parameter that is optimal with respect to a measure of relative error.

This randomized trial compared time-restricted eating with eating over a period of 12 or more hours while matching weight-loss counseling across groups to determine whether practicing TRE by eating early in the day is more effective for weight loss, fat loss, and cardiometabolic health.

Semaglutide treatment in a regular clinical setting was associated with weight loss similar to that seen in randomized clinical trials, which suggests its applicability for treating patients with overweight or obesity.

The ability of these intermittent fasting protocols to help to manage weight long-term is still poorly understood, as the majority of studies to date have run for short durations.

It is shown that both human and mouse adipose tissues retain cellular transcriptional changes after appreciable weight loss and stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to the problematic ‘yo-yo’ effect often seen with dieting.

The baseline gut microbiota was found to excel as a central personal factor in capturing the relationship between dietary factors and weight loss among individuals on a dieting program.

Most studies reporting large weight loss and relevant outcomes used bariatric surgery or lifestyle modifications, and this study reviewed the effect of large weight Loss (≥10%).

This study provides a critical overview of experimental studies in vitro, in humans, and in animals that evaluated the efficacy of Berberine and its effect on management of obesity and the related metabolic consequences.

This study shows that new anti-diabetic drugs, particularly GLP1-RA and Tirzepatide, are the most effective in inducing weight loss in patients with type 2 diabetes.

In conclusion, HPD is an effective and safe tool for weight reduction that can prevent obesity and obesity-related diseases, however, long-term clinical trials spanning more than 12 months should be conducted to further substantiate HPD effects.

A comprehensive literature review of the recent neuroimaging advances on the underlying neural mechanisms of both obesity and interventions is provided, in the hope of guiding development of novel and effective treatments.

Results from clinical trials on drugs acting via weight loss with those exerting no weight loss are compared and other drugs in development directly targeting hepatic lipid metabolism (lipogenesis inhibitors, FGF21 analogs) are addressed.

A fifth of the patients undergoing bariatric surgery may not lose enough weight to be considered successful by current standards, but some patients may benefit from the surgery in the short term, but they are more likely to regain weight after 2 years.

It is shown that RS supplementation for 8 weeks can help to achieve weight loss and improve insulin resistance in individuals with excess body weight and that the gut microbiota is essential for the action of RS.

Background Obesity and lack of physical activity are major health risk factors for many life-threatening diseases, such as cardiovascular diseases, type 2 diabetes, and cancer. The use of mobile app interventions to promote weight loss and boost physical activity among children and adults is fascinating owing to the demand for cutting-edge and more efficient interventions. Previously published studies have examined different types of technology-based interventions and their impact on weight loss and increase in physical activity, but evidence regarding the impact of only a mobile phone app on ...

Specific strains belonging to the genus Lactobacillus and Bifidobacterium were the most used and those that showed the best results in reducing body weight.

It is suggested that time-restricted eating may be an effective alternative strategy to CR for lowering body weight and HbA1c levels in T2D.

An 8-week interdisciplinary weight loss and lifestyle intervention significantly improved OSA severity and other outcomes compared with usual care alone and might be considered as a central strategy to address OSA and comorbidities.

It is shown that weight loss reduces diabetes risk, but inflammatory adipose immune cell populations persist and may contribute to worsened diabetes risk upon weight regain and an open-access web portal of diet-induced AT immune cell imprinting is provided.

Subgroup analyses showed that smartphones were the most effective mHealth approach to achieve weight management and the effect of behavioral weight management interventions using lifestyle mHealth self-monitoring was more pronounced when compared to usual care and in the short-term (less than six months).

Time-restricted eating is more effective in producing weight loss when compared with control but not more effective than CR in a racially diverse population of adults with obesity.

This paper investigates several aspects of training a RNN (recurrent neural network) that impact the objective and subjective quality of enhanced speech for real-time single-channel speech enhancement and proposes two novel mean-squared-error-based learning objectives.

Examination of literature on the outcomes of lifestyle, diet, medications and surgical treatments for obesity using literature searches for obesity treatments yielded evidence supporting baseline and process predictors, but the effect sizes associated with these predictors are small and there are no prospective studies showing that a personalized approach based on genotype or phenotype will yield uniform success.