Browse 200,000,000+ Research Papers

This analysis establishes a foundational framework for forthcoming research and development at the intersection of QC and machine learning, ultimately paving the way for innovative approaches to addressing complex challenges within the healthcare domain.

Higher RA disease activity was associated with accelerated eGFR decline and increased risk of clinically relevant kidney dysfunction and future intervention studies should attempt to replicate the association between RA disease activity and eGFR.

Severe chronic rhinosinusitis with nasal polyps (CRSwNP) is a debilitating disease with a significant impact on the quality of life (QoL). It is typically characterized by a type 2 inflammatory reaction and by comorbidities such as asthma, allergies and NSAID-Exacerbated Respiratory Disease (N-ERD). Here, the European Forum for Research and Education in Allergy and Airway diseases discusses practical guidelines for patients on biologic treatment. Criteria for the selection of patients who would benefit from biologics were updated. Guidelines are proposed concerning the monitoring of the drug e...

Aerogels are a class of lightweight, nanoporous, and nanostructured materials with diverse chemical compositions and a huge potential for applications in a broad spectrum of fields. This has led the IUPAC to include them in the top ten emerging technologies in chemistry for 2022. This review provides an overview of aerogel-based adsorbents that have been used for the removal and recovery of uranium from aqueous environments, as well as an insight into the physicochemical parameters affecting the adsorption efficiency and mechanism. Uranium removal is of particular interest regarding uranium an...

ABSTRACT Microplastic (MP) is an emerging contaminant of concern due to its abundance in the environment. Wastewater treatment plant (WWTP) can be considered as one of the main sources of microplastics in freshwater due to its inefficiency in the complete removal of small MPs. In this study, a column-based MP removal which could serve as a tertiary treatment in WWTPs is evaluated using granular activated carbon (GAC) as adsorbent/filter media, eliminating clogging problems commonly caused by powder form activated carbon (PAC). The GAC is characterized via N2 adsorption–desorption isotherm, fie...

Variation in initial treatment with anakinra is characterized and cardiovascular outcomes associated with adding anakinRA to standard initial therapy are evaluated.

In this review, the recent advances in nanomaterials for NIR‐II PAI are summarized, including the advantages of NIR •I PAI and the applications of nanomMaterials‐based Nir‐IIPAI in biomedical field.

A Hyperledger Fabric blockchain-based secure data transfer scheme for enterprises in the Industrial Internet of Things (IIOT), which uses Fabric’s channel mechanism combined with Chaincode to achieve privacy protection and efficient data transmission while using the Elliptic Curve Digital Signature Algorithm (ECDSA) to ensure data integrity.

In order to study the impact of a renewable energy quota and green power certificate system on the strategies of energy suppliers, this paper constructs a multi-stage game model of renewable energy power investment and production from the renewable energy interest chain and its stakeholders. Through the calculation and solution of the model, the optimal renewable energy utilization level, pricing and production strategies of renewable energy power of energy suppliers are calculated under the scenarios of direct sale of power and purchase and sale by power grids. The results show that the quota...

A genome-wide meta-analysis of IPF risk across three studies with independent replication of associated variants in two additional studies identified five robust novel genetic association signals implicating mTOR (mammalian target of rapamycin) signalling, telomere maintenance and spindle assembly genes in IPFrisk.

This paper proposes an evolutionary view of economic catch-up by latecomers, considered as a long-run process of closing the gap in capabilities by promoting learning and innovation in interaction with innovation systems (national, sectoral or regional). According to this perspective, catch-up is viewed as a dynamic evolutionary process which is not deterministic and cannot be planned in details because it faces uncertainty and continuous change; is associated with a variety of exogenous events (windows of opportunity) and is the result of the idiosyncratic behavior of heterogeneous actors c...

Macrophages may have a leading role in OA progression through the NF-kB production of inflammatory factors (iNOS and MMP-9) in the intima, except in advanced OA, where leukocytes could have a dominant role through NF-MB production in subintima.

This work demonstrates that SDC4 is the only SDC whose gene expression is upregulated during pathological angiogenesis and is selectively enriched on immature vessels in retinas from diabetic retinopathy patients and a potential target for antiangiogenic therapies.

This study demonstrates that GSAP regulates lipid homeostasis in mitochondria-associated membranes (MAM), which affects mitochondrial function associated with the disease.

ABSTRACT It is widely recognised that energy poverty can have serious and detrimental impacts upon multiple aspects of people’s well-being and life quality. This paper seeks to provide a multi-dimensional and theoretically-attuned account of the relations between energy poverty and well-being, through the use of the Capabilities Approach and specifically Nussbaum’s normative theory of Central Capabilities. Drawing on interviews with 109 households in 4 European countries, we demonstrate how 6 of the 10 Central Capabilities – namely Bodily Health, Emotions, Affiliation, Play, Practical Reason a...

Current evidence does not show consistent associations of WASH conditions and interventions with prevention of acute malnutrition or with the improvement of its treatment outcomes, and highlights the need for high‐quality, rigorous intervention studies assessing the effects of Wash interventions specifically designed to prevent acute childhood malnutrition or improve its treatment.

Findings support evidence that CK induces apoptosis via the activation of miR193a-5p and inhibition of PD-L1 and STAT3 signaling in prostate cancer cells.

The aim of the current study was to present norm values and psychometric properties of the Checklist Individual Strength (CIS) and Short Fatigue Questionnaire (SFQ) in a nationwide cohort of CCS.

All microbes have great potential for the treatment and valorisation of textile wastewater after tailored adaptation phases, yet, the depurative efficiency can be probably enhanced by combining the different processes in sequence.

This study describes the properties of geopolymer composites reinforced with bidirectional jute fibers. Their flexural strength is 12 MPa, four times higher than the strength of non-reinforced reference geopolymers. The bidirectional jute-reinforced geopolymer composite (JGC) is characterized by ductility and high elongation as well as strain hardening with a modulus of 66 MPa. It is found that the introduction of bidirectional jute fibers in the geopolymer matrix increases the adsorption capacity of Cr ions from 2.7 to 6.4 mg/g (pH = 5). The JGC can be recycled by grinding the material, and t...