Advances in metabolic engineering of <i>Corynebacterium glutamicum</i> to produce high-value active ingredients for food, feed, human health, and well-being
Recent advances in engineering of the soil microbe Corynebacterium glutamicum into novel cell factories that overproduce these precious molecules from pioneering proofs-of-concept up to industrial productivity are highlighted.
Abstract
<jats:title>Abstract</jats:title> <jats:p>The soil microbe Corynebacterium glutamicum is a leading workhorse in industrial biotechnology and has become famous for its power to synthetise amino acids and a range of bulk chemicals at high titre and yield. The product portfolio of the microbe is continuously expanding. Moreover, metabolically engineered strains of C. glutamicum produce more than 30 high value active ingredients, including signature molecules of raspberry, savoury, and orange flavours, sun blockers, anti-ageing sugars, and polymers for regenerative medicine. Herein, we highlight recent advances in engineering of the microbe into novel cell factories that overproduce these precious molecules from pioneering proofs-of-concept up to industrial productivity.</jats:p>